移植后淋巴细胞增生性疾病（肾脏病研讨会综述）。

IF 2.8 3区医学 Q2 UROLOGY & NEPHROLOGY

Seminars in nephrology Pub Date : 2024-01-01 DOI:10.1016/j.semnephrol.2024.151503

Vikas R. Dharnidharka MD, MPH , Marianna B. Ruzinova MD, PhD , Lianna J. Marks MD

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引用次数: 0

摘要

移植后淋巴组织增生性疾病（PTLDs）是器官或组织移植后出现的一系列不规则淋巴细胞增生。大多数病例与 Epstein-Barr 病毒和较高强度的药物免疫抑制有关。临床表现多种多样。理想的诊断方法是进行组织学检查，除非肿瘤无法进行活检。虽然一些先发制人的疗法和治疗策略取得了一定的成功，但它们并不能消除 PTLD 的高发病率和高死亡率。

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Post-Transplant Lymphoproliferative Disorders

Post-transplant lymphoproliferative disorders (PTLDs) are a heterogenous set of unregulated lymphoid cell proliferations after organ or tissue transplant. A majority of cases are associated with the Epstein-Barr virus and higher intensity of pharmacologic immunosuppression. The clinical presentations are numerous. The diagnosis is ideally by histology, except in cases where the tumor is inaccessible to biopsy. While some pre-emptive therapies and treatment strategies are available have reasonable success are available, they do not eliminate the high morbidity and significant mortality after PTLD.

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来源期刊

Seminars in nephrology 医学-泌尿学与肾脏学

CiteScore

5.60

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Seminars in Nephrology is a timely source for the publication of new concepts and research findings relevant to the clinical practice of nephrology. Each issue is an organized compendium of practical information that serves as a lasting reference for nephrologists, internists and physicians in training.