结合代谢组学和网络药理学评估麻黄细辛附子煎剂对硝酸甘油诱导的偏头痛大鼠的影响

IF 2.8 4区 医学 Q2 PHARMACOLOGY & PHARMACY
Fei Ge, Yao Zhang, Yamin Luo, Chunguo Wang, Yixing Lu, Yafang Zhao, Di Zhang, Fengxian Meng, Dongmei Zhang, Meng Chen, Xiaohua Tao
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引用次数: 0

摘要

目的:本研究旨在探讨麻黄细辛附子汤对偏头痛的药理活性和治疗机制:本研究旨在探讨麻黄细辛附子汤(MXFD)对偏头痛的药理活性和治疗机制:方法:建立硝酸甘油诱导的偏头痛模型大鼠,口服麻黄细辛附子汤 7 天。方法:建立硝酸甘油诱导的偏头痛模型大鼠,然后口服 MXFD 7 天,收集血液和尿液样本,用代谢组学方法鉴定不同的代谢物。综合网络药理学和代谢组学的分析结果,筛选出与MXFD治疗偏头痛相关的代谢物和靶点:主要发现:MXFD可减轻大鼠的偏头痛症状。经 MXFD 治疗后,9 种代谢物得到调节并恢复到正常水平。MXFD 直接作用于九个关键靶点,包括 MAOB、MAOA、ADRB1、ADRB2、ADRB3、ADORA2A、ADORA2B、DRD5 和 HTR4,并调节了九个代谢物中的两个,即脱氧胆酸和 5-甲氧基吲哚乙酸:研究发现,MXFD 可通过多靶点和多成分相互作用网络缓解偏头痛。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Integrating metabolomics and network pharmacology to assess the effects of Mahuang Xixin Fuzi decoction on migraine rats induced by nitroglycerin.

Objectives: This study was designed to investigate the pharmacological activity and therapeutic mechanism of Mahuang Xixin Fuzi decoction (MXFD) on migraine.

Methods: Migraine model rats induced by nitroglycerin were established, and then orally administered with MXFD for 7 days. Blood and urine samples were collected to identify differential metabolites with metabolomics. To integrate the findings from network pharmacology and metabolomics analysis, the metabolites and targets related to MXFD therapy for migraine were filtered.

Key findings: MXFD was found to alleviate the symptoms of migraines in rats. After treatment with MXFD, nine metabolites were found to be regulated and returned to normal levels. MXFD acted directly on nine key targets including MAOB, MAOA, ADRB1, ADRB2, ADRB3, ADORA2A, ADORA2B, DRD5, and HTR4 and regulated two out of nine metabolites, namely deoxycholic acid and 5-methoxyindoleacetate.

Conclusions: The study found that MXFD can alleviate migraines through multitarget and multicomponent interaction networks.

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来源期刊
CiteScore
6.60
自引率
0.00%
发文量
91
审稿时长
3 months
期刊介绍: JPP keeps pace with new research on how drug action may be optimized by new technologies, and attention is given to understanding and improving drug interactions in the body. At the same time, the journal maintains its established and well-respected core strengths in areas such as pharmaceutics and drug delivery, experimental and clinical pharmacology, biopharmaceutics and drug disposition, and drugs from natural sources. JPP publishes at least one special issue on a topical theme each year.
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