绝经后妇女服用精神药物与身体功能的关系。

IF 5.3 2区 医学 Q1 GERIATRICS & GERONTOLOGY
GeroScience Pub Date : 2024-12-01 Epub Date: 2024-03-22 DOI:10.1007/s11357-024-01141-z
Hind A Beydoun, May A Beydoun, Edward Kwon, Brook T Alemu, Alan B Zonderman, Robert Brunner
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引用次数: 0

摘要

研究精神药物与绝经后身体功能的横向和纵向关系。分析涉及 4557 名妇女健康倡议长寿研究(WHI-LLS)参与者(WHI 注册时(1993-1998 年)的平均年龄为 62.8 岁):62.8岁)。在WHI注册和3年随访时对抗抑郁、抗焦虑和镇静/催眠药物进行了评估。2012-2013年WHI-LLS随访时对基于表现的身体功能[短期身体表现测试(SPPB)]进行了评估。自我报告的身体功能[RAND-36]是在WHI注册和最后一次随访时进行的,平均为注册后22[±2.8]年(范围:12-27)。多变量回归模型控制了社会人口学、生活方式和健康特征。抗焦虑药与身体功能无关。在加入WHI时,抗抑郁药的使用与自我报告的身体机能下降有横截面关系,后者被定义为连续结果(β = -6.27,95% 置信区间 [CI]:-8.48,-4.07)或分类结果(< 78 vs. ≥ 78)(几率比 [OR] = 2.10,95% CI:1.48,2.98)。在2012-2013年WHI-LLS检查中,在WHI注册时使用抗抑郁药也与基于表现的身体功能(SPPB)[< 10 vs. ≥ 10](OR = 1.53,95% CI:1.05, 2.21)较差有关。与不使用镇静剂/催眠药的患者相比,在WHI注册时使用镇静剂/催眠药但在3年随访时未使用镇静剂/催眠药的患者在WHI注册和随访期间身体功能下降更快。在绝经后妇女中,使用抗抑郁药与自我报告的身体功能较差有横断面关系,与随访20年以上后基于表现的身体功能较差有横断面关系。催眠药/镇静剂的复杂关系出乎意料,需要进一步研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Relationship of psychotropic medication use with physical function among postmenopausal women.

Relationship of psychotropic medication use with physical function among postmenopausal women.

To examine cross-sectional and longitudinal relationships of psychotropic medications with physical function after menopause. Analyses involved 4557 Women's Health Initiative Long Life Study (WHI-LLS) participants (mean age at WHI enrollment (1993-1998): 62.8 years). Antidepressant, anxiolytic, and sedative/hypnotic medications were evaluated at WHI enrollment and 3-year follow-up visits. Performance-based physical function [Short Physical Performance Battery (SPPB)] was assessed at the 2012-2013 WHI-LLS visit. Self-reported physical function [RAND-36] was examined at WHI enrollment and the last available follow-up visit-an average of 22 [±2.8] (range: 12-27) years post-enrollment. Multivariable regression models controlled for socio-demographic, lifestyle, and health characteristics. Anxiolytics were not related to physical function. At WHI enrollment, antidepressant use was cross-sectionally related to worse self-reported physical function defined as a continuous (β = -6.27, 95% confidence interval [CI]: -8.48, -4.07) or as a categorical (< 78 vs. ≥ 78) (odds ratio [OR] = 2.10, 95% CI: 1.48, 2.98) outcome. Antidepressant use at WHI enrollment was also associated with worse performance-based physical function (SPPB) [< 10 vs. ≥ 10] (OR = 1.53, 95% CI: 1.05, 2.21) at the 2012-2013 WHI-LLS visit. Compared to non-users, those using sedative/hypnotics at WHI enrollment but not at the 3-year follow-up visit reported a faster decline in physical function between WHI enrollment and follow-up visits. Among postmenopausal women, antidepressant use was cross-sectionally related to worse self-reported physical function, and with worse performance-based physical function after > 20 years of follow-up. Complex relationships found for hypnotic/sedatives were unexpected and necessitate further investigation.

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来源期刊
GeroScience
GeroScience Medicine-Complementary and Alternative Medicine
CiteScore
10.50
自引率
5.40%
发文量
182
期刊介绍: GeroScience is a bi-monthly, international, peer-reviewed journal that publishes articles related to research in the biology of aging and research on biomedical applications that impact aging. The scope of articles to be considered include evolutionary biology, biophysics, genetics, genomics, proteomics, molecular biology, cell biology, biochemistry, endocrinology, immunology, physiology, pharmacology, neuroscience, and psychology.
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