慢性阻塞性肺病严重恶化发作时的血小板计数和血小板与淋巴细胞比率与下次中度或严重复发的时间无关。

IF 2.5 4区医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

Advances in medical sciences Pub Date : 2024-03-01 DOI:10.1016/j.advms.2024.03.003

Andreas Schønberg-Moe , Balázs Csoma , András Bikov , Veronika Müller , Zsófia Lázár

{"title":"慢性阻塞性肺病严重恶化发作时的血小板计数和血小板与淋巴细胞比率与下次中度或严重复发的时间无关。","authors":"Andreas Schønberg-Moe , Balázs Csoma , András Bikov , Veronika Müller , Zsófia Lázár","doi":"10.1016/j.advms.2024.03.003","DOIUrl":null,"url":null,"abstract":"<div><h3>Purpose</h3><p>Acute exacerbations (AE) are severe complications of chronic obstructive pulmonary disease (COPD); however, the need for biomarkers which predict them is still unmet. High platelet count (PLC) and platelet-to-lymphocyte ratio (PLR) are associated with higher mortality in patients with COPD. We investigated if PLC and PLR at the onset of a severe AE could predict the time of the next relapse.</p></div><div><h3>Methods</h3><p>In a prospective observational cohort study, data of 152 patients hospitalized with AECOPD were collected, and patients were divided into PLC-low (<239 × 10<sup>9</sup>/L, n = 51), PLC-medium (239-297 × 10<sup>9</sup>/L, n = 51) and PLC-high (>297 × 10<sup>9</sup>/L, n = 50) or PLR-low (<147, N = 51), PLR-medium (147–295, n = 51) and PLR high (>295, n = 50) groups based on PLC and PLR tertiles using admission laboratory results. Clinical characteristics and the time to the next severe or moderate AE within 52 weeks were compared among subgroups using log-rank test.</p></div><div><h3>Results</h3><p>PLC and PLR tertiles did not differ in clinical characteristics or the time till the next AE (p > 0.05). PLC and PLR showed a direct weak correlation to neutrophil count (Pearson r = 0.26, p < 0.01 and r = 0.20, p = 0.01) and PLC also demonstrated a weak relationship to white blood cell counts (Pearson r = 0.29, p < 0.001). However, PLR presented an inverse relationship to monocyte and eosinophil counts (r = −0.32, p < 0.001 and r = −0.17, p = 0.03).</p></div><div><h3>Conclusion</h3><p>PLC and PLR do not predict the time till the next relapse; however, they may reflect on neutrophilic inflammatory response during an exacerbation of COPD.</p></div>","PeriodicalId":7347,"journal":{"name":"Advances in medical sciences","volume":"69 1","pages":"Pages 160-166"},"PeriodicalIF":2.5000,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Platelet count and platelet-to-lymphocyte ratio at the onset of a severe COPD exacerbation are unrelated to the time till the next moderate or severe relapse\",\"authors\":\"Andreas Schønberg-Moe , Balázs Csoma , András Bikov , Veronika Müller , Zsófia Lázár\",\"doi\":\"10.1016/j.advms.2024.03.003\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Purpose</h3><p>Acute exacerbations (AE) are severe complications of chronic obstructive pulmonary disease (COPD); however, the need for biomarkers which predict them is still unmet. High platelet count (PLC) and platelet-to-lymphocyte ratio (PLR) are associated with higher mortality in patients with COPD. We investigated if PLC and PLR at the onset of a severe AE could predict the time of the next relapse.</p></div><div><h3>Methods</h3><p>In a prospective observational cohort study, data of 152 patients hospitalized with AECOPD were collected, and patients were divided into PLC-low (<239 × 10<sup>9</sup>/L, n = 51), PLC-medium (239-297 × 10<sup>9</sup>/L, n = 51) and PLC-high (>297 × 10<sup>9</sup>/L, n = 50) or PLR-low (<147, N = 51), PLR-medium (147–295, n = 51) and PLR high (>295, n = 50) groups based on PLC and PLR tertiles using admission laboratory results. Clinical characteristics and the time to the next severe or moderate AE within 52 weeks were compared among subgroups using log-rank test.</p></div><div><h3>Results</h3><p>PLC and PLR tertiles did not differ in clinical characteristics or the time till the next AE (p > 0.05). PLC and PLR showed a direct weak correlation to neutrophil count (Pearson r = 0.26, p < 0.01 and r = 0.20, p = 0.01) and PLC also demonstrated a weak relationship to white blood cell counts (Pearson r = 0.29, p < 0.001). However, PLR presented an inverse relationship to monocyte and eosinophil counts (r = −0.32, p < 0.001 and r = −0.17, p = 0.03).</p></div><div><h3>Conclusion</h3><p>PLC and PLR do not predict the time till the next relapse; however, they may reflect on neutrophilic inflammatory response during an exacerbation of COPD.</p></div>\",\"PeriodicalId\":7347,\"journal\":{\"name\":\"Advances in medical sciences\",\"volume\":\"69 1\",\"pages\":\"Pages 160-166\"},\"PeriodicalIF\":2.5000,\"publicationDate\":\"2024-03-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Advances in medical sciences\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1896112624000166\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"MEDICINE, RESEARCH & EXPERIMENTAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advances in medical sciences","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1896112624000166","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MEDICINE, RESEARCH & EXPERIMENTAL","Score":null,"Total":0}

引用次数: 0

摘要

目的：急性加重（AE）是慢性阻塞性肺病（COPD）的严重并发症；然而，预测急性加重的生物标志物的需求仍未得到满足。高血小板计数（PLC）和血小板淋巴细胞比值（PLR）与慢性阻塞性肺病患者较高的死亡率有关。我们研究了严重急性呼吸衰竭发病时的血小板计数和血小板淋巴细胞比值能否预测下次复发的时间：在一项前瞻性观察性队列研究中，我们收集了152名AECOPD住院患者的数据，并根据入院实验室结果将患者分为PLC低（9/L，n = 51）、PLC中（239-297 × 109/L，n = 51）和PLC高（>297 × 109/L，n = 50）或PLR低（295，n = 50）组。采用对数秩检验比较了各亚组的临床特征以及在52周内发生下一次严重或中度AE的时间：结果：PLC和PLR三分位数在临床特征和下一次AE发生时间上没有差异（P > 0.05）。PLC和PLR与中性粒细胞计数呈弱直接相关（Pearson r = 0.26，P 结论：PLC和PLR不能预测中性粒细胞计数：PLC和PLR不能预测下一次复发的时间；但是，它们可能反映了慢性阻塞性肺疾病加重时中性粒细胞的炎症反应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Platelet count and platelet-to-lymphocyte ratio at the onset of a severe COPD exacerbation are unrelated to the time till the next moderate or severe relapse

Purpose

Acute exacerbations (AE) are severe complications of chronic obstructive pulmonary disease (COPD); however, the need for biomarkers which predict them is still unmet. High platelet count (PLC) and platelet-to-lymphocyte ratio (PLR) are associated with higher mortality in patients with COPD. We investigated if PLC and PLR at the onset of a severe AE could predict the time of the next relapse.

Methods

In a prospective observational cohort study, data of 152 patients hospitalized with AECOPD were collected, and patients were divided into PLC-low (<239 × 10⁹/L, n = 51), PLC-medium (239-297 × 10⁹/L, n = 51) and PLC-high (>297 × 10⁹/L, n = 50) or PLR-low (<147, N = 51), PLR-medium (147–295, n = 51) and PLR high (>295, n = 50) groups based on PLC and PLR tertiles using admission laboratory results. Clinical characteristics and the time to the next severe or moderate AE within 52 weeks were compared among subgroups using log-rank test.

Results

PLC and PLR tertiles did not differ in clinical characteristics or the time till the next AE (p > 0.05). PLC and PLR showed a direct weak correlation to neutrophil count (Pearson r = 0.26, p < 0.01 and r = 0.20, p = 0.01) and PLC also demonstrated a weak relationship to white blood cell counts (Pearson r = 0.29, p < 0.001). However, PLR presented an inverse relationship to monocyte and eosinophil counts (r = −0.32, p < 0.001 and r = −0.17, p = 0.03).

Conclusion

PLC and PLR do not predict the time till the next relapse; however, they may reflect on neutrophilic inflammatory response during an exacerbation of COPD.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Advances in medical sciences 医学-医学：研究与实验

CiteScore

5.00

自引率

0.00%

发文量

审稿时长

25 days

期刊介绍： Advances in Medical Sciences is an international, peer-reviewed journal that welcomes original research articles and reviews on current advances in life sciences, preclinical and clinical medicine, and related disciplines. The Journal’s primary aim is to make every effort to contribute to progress in medical sciences. The strive is to bridge laboratory and clinical settings with cutting edge research findings and new developments. Advances in Medical Sciences publishes articles which bring novel insights into diagnostic and molecular imaging, offering essential prior knowledge for diagnosis and treatment indispensable in all areas of medical sciences. It also publishes articles on pathological sciences giving foundation knowledge on the overall study of human diseases. Through its publications Advances in Medical Sciences also stresses the importance of pharmaceutical sciences as a rapidly and ever expanding area of research on drug design, development, action and evaluation contributing significantly to a variety of scientific disciplines. The journal welcomes submissions from the following disciplines: General and internal medicine, Cancer research, Genetics, Endocrinology, Gastroenterology, Cardiology and Cardiovascular Medicine, Immunology and Allergy, Pathology and Forensic Medicine, Cell and molecular Biology, Haematology, Biochemistry, Clinical and Experimental Pathology.