具有最佳水抑制功能的超洁净纯移位 NMR，用于分析水性药品样品

IF 3.3 3区化学 Q2 CHEMISTRY, ANALYTICAL

Analyst Pub Date : 2024-03-22 DOI:10.1039/D3AN02150E

Guilherme Dal Poggetto, Adam DiCaprio, Mikhail Reibarkh and Ryan D. Cohen

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引用次数: 0

摘要

纯移位 NMR 实验通过将多重子结构折叠成单子结构，极大地提高了光谱分辨率，并且通过水抑制，可用于水性样品。在此，我们将超洁净纯移位 NMR (SAPPHIRE) 与两种不同的内部编码水抑制方案相结合，以实现小分子和大环肽药物在水和乙腈-水混合物中的最佳性能。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Ultra-clean pure shift NMR with optimal water suppression for analysis of aqueous pharmaceutical samples†

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Ultra-clean pure shift NMR with optimal water suppression for analysis of aqueous pharmaceutical samples†

Pure shift NMR experiments greatly enhance spectral resolution by collapsing multiplet structures into singlets and, with water suppression, can be used for aqueous samples. Here, we combine ultra-clean pure-shift NMR (SAPPHIRE) with two different internally encoded water suppression schemes to achieve optimal performance for small molecule and macrocyclic peptide pharmaceuticals in water and acetonitrile–water mixtures.

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