Maximo J Marin, Xander M R van Wijk, Allison B Chambliss
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引用次数: 0
摘要
败血症是宿主对感染性病原体的一种失调免疫反应，它大大增加了全球住院病人的发病率和死亡率。本章回顾了：(1) 感染性疾病的基本原理、病理生理学和脓毒症的当前定义；(2) 已确立的脓毒症生物标志物，如乳酸、降钙素原和 C 反应蛋白；(3) 新近获得监管部门批准/认可的新型生物标志物，如评估白细胞特性和免疫反应分子的检测方法；(4) 新出现的生物标志物和生物标志物面板，以突出脓毒症诊断和管理的未来方向和机遇。
Sepsis, a dysregulated host immune response to an infectious agent, significantly increases morbidity and mortality for hospitalized patients worldwide. This chapter reviews (1) the basic principles of infectious diseases, pathophysiology and current definition of sepsis, (2) established sepsis biomarkers such lactate, procalcitonin and C-reactive protein, (3) novel, newly regulatory-cleared/approved biomarkers, such as assays that evaluate white blood cell properties and immune response molecules, and (4) emerging biomarkers and biomarker panels to highlight future directions and opportunities in the diagnosis and management of sepsis.
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