早期运动发育与儿童和青少年运动行为之间的遗传混淆。

IF 5.6 1区 医学 Q1 NUTRITION & DIETETICS
Yahua Zi, Meike Bartels, Conor Dolan, Eco J C de Geus
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引用次数: 0

摘要

简介:研究发现,早期运动发育是儿童和青少年运动行为的预测因素:研究发现,早期运动发育可预测儿童和青少年的运动行为,但这是否反映了因果效应或遗传或共同环境因素的干扰,仍有待确定:方法:对来自荷兰双胞胎登记处的 20,911 对完整双胞胎进行了运动发育评分,评分来自母亲对五个运动里程碑时间的报告。在为期12年的随访中,母亲的子样本报告了双胞胎在7岁(3632对)、10岁(3735对)、12岁(7043对)和14岁(3990对)时的七种粗大运动技能能力(17189对)以及每周用于运动和锻炼活动的总代谢当量(MET)分钟数。通过多变量表型和遗传回归分析,确定了两个运动发育特征对未来运动行为的预测强度、遗传和共同环境因素对所有特征变异的贡献,以及家族混杂因素对表型预测的贡献:结果:在男孩和女孩的早期运动发育中,发现了显著的遗传效应(h2)和共同环境效应(c2)(h2 = 43-65%;c2 = 16-48%)。在运动行为方面,遗传影响随着年龄的增长而增加(男孩:h2age7 = 22% 到 h2age14 = 51%;女孩:h2age7 = 3% 到 h2age14 = 18%),与此同时,共同环境的影响却在减少(男孩:c2age7 = 68% 到 c2age14 = 19%;女孩:c2age7 = 80% 到 c2age14 = 48%)。早期运动发展解释了 4.3%(P没有发现早期快速运动发育与未来运动行为之间的直接因果关系。在男孩中,早期运动发育似乎是导致儿童和青少年早期运动行为遗传性的相同遗传因素的表现。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Genetic confounding in the association of early motor development with childhood and adolescent exercise behavior.

Introduction: Early motor development has been found to be a predictor of exercise behavior in children and adolescents, but whether this reflects a causal effect or confounding by genetic or shared environmental factors remains to be established.

Methods: For 20,911 complete twin pairs from the Netherlands Twin Register a motor development score was obtained from maternal reports on the timing of five motor milestones. During a 12-year follow-up, subsamples of the mothers reported on the twins' ability to perform seven gross motor skills ability (N = 17,189 pairs), and weekly minutes of total metabolic equivalents of task (MET) spent on sports and exercise activities at age 7 (N = 3632 pairs), age 10 (N = 3735 pairs), age 12 (N = 7043 pairs), and age 14 (N = 3990 pairs). Multivariate phenotypic and genetic regression analyses were used to establish the predictive strength of the two motor development traits for future exercise behavior, the contribution of genetic and shared environmental factors to the variance in all traits, and the contribution of familial confounding to the phenotypic prediction.

Results: Significant heritability (h2) and shared environmental (c2) effects were found for early motor development in boys and girls (h2 = 43-65%; c2 = 16-48%). For exercise behavior, genetic influences increased with age (boys: h2age7 = 22% to h2age14 = 51%; girls: h2age7 = 3% to h2age14 = 18%) paired to a parallel decrease in the influence of the shared environment (boys: c2age7 = 68% to c2age14 = 19%; girls: c2age7 = 80% to c2age14 = 48%). Early motor development explained 4.3% (p < 0.001) of the variance in future exercise behavior in boys but only 1.9% (p < 0.001) in girls. If the effect in boys was due to a causal effect of motor development on exercise behavior, all of the factors influencing motor development would, through the causal chain, also influence future exercise behavior. Instead, only the genetic parts of the regression of exercise behavior on motor development were significant. Shared and unique environmental parts of the regression were largely non-significant, which is at odds with the causal hypothesis.

Conclusion: No support was found for a direct causal effect in the association between rapid early motor development on future exercise behavior. In boys, early motor development appears to be an expression of the same genetic factors that underlie the heritability of childhood and early adolescent exercise behavior.

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来源期刊
CiteScore
13.80
自引率
3.40%
发文量
138
审稿时长
4-8 weeks
期刊介绍: International Journal of Behavioral Nutrition and Physical Activity (IJBNPA) is an open access, peer-reviewed journal offering high quality articles, rapid publication and wide diffusion in the public domain. IJBNPA is devoted to furthering the understanding of the behavioral aspects of diet and physical activity and is unique in its inclusion of multiple levels of analysis, including populations, groups and individuals and its inclusion of epidemiology, and behavioral, theoretical and measurement research areas.
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