巴西狼疮性肾炎患者的流行病学、免疫学和治疗反应概况。

IF 1.9 4区 医学 Q3 RHEUMATOLOGY
Lupus Pub Date : 2024-05-01 Epub Date: 2024-03-21 DOI:10.1177/09612033241240869
Mariana Sousa Teixeira Nunes, Lectícia Barbosa Jorge, Luis Yu, Viktoria Woronik, Cristiane Bitencourt Dias
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引用次数: 0

摘要

背景与假设:巴西是非洲以外非洲裔人数最多的国家,也是混血人口最多的国家。在巴西的狼疮性肾炎(LN)病例中,发病率甚至严重程度都存在差异,这取决于研究地点和研究人群的特征。本研究旨在描述巴西狼疮性肾炎的临床和流行病学特征,并确定这些特征中哪些是肾脏预后不良的风险因素:这是一项回顾性、描述性观察研究,研究对象是1999年至2015年间在巴西圣保罗 Clínicas 医院肾内科接受肾活检的 LN 患者。数据来自电子病历:我们对398名患者进行了评估,其中94.1%和77.7%的患者抗核抗体和抗DNA抗体检测呈阳性,33.7%的患者呈全屋模式。从 LN 症状出现到活检的时间是结论:晚期活组织检查似乎与 LN 患者的肾脏不良预后有关。不过,在巴西,较高的慢性化指数似乎是预测 LN 患者不良肾脏预后的主要因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Epidemiological, immunological, and treatment response profile of patients with lupus nephritis in Brazil.

Background and hypothesis: Brazil has the largest number of individuals of African descent outside Africa and a very admixed population. Among cases of lupus nephritis (LN) in the country, there are differences in incidence, and even in severity, depending on the location and characteristics of the population studied. The aim of this study was to describe the clinical and epidemiological characteristics of LN in Brazil, as well as to determine which of those characteristics would be risk factors for a poor renal prognosis.

Methods: This was a retrospective, descriptive observational study of patients diagnosed with LN who underwent kidney biopsy between 1999 and 2015 in the Nephrology Department of the Hospital das Clínicas, in São Paulo, Brazil. Data were collected from electronic medical records.

Results: We evaluated 398 patients, among who 94.1% and 77.7% tested positive for antinuclear antibodies and anti-DNA antibodies, respectively, whereas 33.7% showed the full-house pattern. The time from LN symptom onset to biopsy was <6 months in 47.5% (early biopsy group) and ≥6 months in 52.5% (late biopsy group). In the early biopsy group, the chronicity index was lower and the activity index was higher. Multivariate analysis showed that a higher chronicity index was the only independent risk factor for progression to requiring kidney replacement therapy.

Conclusion: Late biopsy seems to be associated with negative renal outcomes in LN. However, it seems that a higher chronicity index is the main predictor of a poor renal outcome among patients with LN in Brazil.

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来源期刊
Lupus
Lupus 医学-风湿病学
CiteScore
4.20
自引率
11.50%
发文量
225
审稿时长
1 months
期刊介绍: The only fully peer reviewed international journal devoted exclusively to lupus (and related disease) research. Lupus includes the most promising new clinical and laboratory-based studies from leading specialists in all lupus-related disciplines. Invaluable reading, with extended coverage, lupus-related disciplines include: Rheumatology, Dermatology, Immunology, Obstetrics, Psychiatry and Cardiovascular Research…
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