Laurel Gardner, Linda E Keyes, Caleb Phillips, Elan Small, Tejaswi Adhikari, Nathan Barott, Ken Zafren, Rony Maharjan, James Marvel
{"title":"高海拔地区的女性:月经周期阶段、绝经期和外源性孕酮与急性晕山症无关。","authors":"Laurel Gardner, Linda E Keyes, Caleb Phillips, Elan Small, Tejaswi Adhikari, Nathan Barott, Ken Zafren, Rony Maharjan, James Marvel","doi":"10.1089/ham.2023.0100","DOIUrl":null,"url":null,"abstract":"<p><p>Gardner, Laurel, Linda E. Keyes, Caleb Phillips, Elan Small, Tejaswi Adhikari, Nathan Barott, Ken Zafren, Rony Maharjan, and James Marvel. Women at altitude: Menstrual-cycle phase, menopause, and exogenous progesterone are not associated with acute mountain sickness. <i>High Alt Med Biol.</i> 00:000-000, 2024. <b><i>Background:</i></b> Elevated progesterone levels in women may protect against acute mountain sickness (AMS). The impact of hormonal contraception (HC) on AMS is unknown. We examined the effect of natural and exogenous progesterone on the occurrence of AMS. <b><i>Methods:</i></b> We conducted a prospective observational convenience study of female trekkers in Lobuche (4,940 m) and Manang (3,519 m). We collected data on last menstrual period, use of exogenous hormones, and development of AMS. <b><i>Results:</i></b> There were 1,161 trekkers who met inclusion criteria, of whom 307 (26%) had AMS. There was no significant difference in occurrence of AMS between women in the follicular (28%) and the luteal (25%) phases of menstruation (<i>p</i> = 0.48). The proportion of premenopausal (25%) versus postmenopausal women (30%) with AMS did not differ (<i>p</i> = 0.33). The use of HC did not influence the occurrence of AMS (HC 23% vs. no HC 26%, <i>p</i> = 0.47), nor did hormonal replacement therapy (HRT) (HRT 11% vs. no HRT 31%, <i>p</i> = 0.13). <b><i>Conclusion:</i></b> We found no relationship between menstrual-cycle phase, menopausal status, or use of exogenous progesterone and the occurrence of AMS in trekkers and conclude that hormonal status is not a risk factor for AMS. Furthermore, women should not be excluded from future AMS studies based on hormonal status.</p>","PeriodicalId":12975,"journal":{"name":"High altitude medicine & biology","volume":null,"pages":null},"PeriodicalIF":1.6000,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Women at Altitude: Menstrual-Cycle Phase, Menopause, and Exogenous Progesterone Are Not Associated with Acute Mountain Sickness.\",\"authors\":\"Laurel Gardner, Linda E Keyes, Caleb Phillips, Elan Small, Tejaswi Adhikari, Nathan Barott, Ken Zafren, Rony Maharjan, James Marvel\",\"doi\":\"10.1089/ham.2023.0100\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Gardner, Laurel, Linda E. Keyes, Caleb Phillips, Elan Small, Tejaswi Adhikari, Nathan Barott, Ken Zafren, Rony Maharjan, and James Marvel. Women at altitude: Menstrual-cycle phase, menopause, and exogenous progesterone are not associated with acute mountain sickness. <i>High Alt Med Biol.</i> 00:000-000, 2024. <b><i>Background:</i></b> Elevated progesterone levels in women may protect against acute mountain sickness (AMS). The impact of hormonal contraception (HC) on AMS is unknown. We examined the effect of natural and exogenous progesterone on the occurrence of AMS. <b><i>Methods:</i></b> We conducted a prospective observational convenience study of female trekkers in Lobuche (4,940 m) and Manang (3,519 m). We collected data on last menstrual period, use of exogenous hormones, and development of AMS. <b><i>Results:</i></b> There were 1,161 trekkers who met inclusion criteria, of whom 307 (26%) had AMS. There was no significant difference in occurrence of AMS between women in the follicular (28%) and the luteal (25%) phases of menstruation (<i>p</i> = 0.48). The proportion of premenopausal (25%) versus postmenopausal women (30%) with AMS did not differ (<i>p</i> = 0.33). The use of HC did not influence the occurrence of AMS (HC 23% vs. no HC 26%, <i>p</i> = 0.47), nor did hormonal replacement therapy (HRT) (HRT 11% vs. no HRT 31%, <i>p</i> = 0.13). <b><i>Conclusion:</i></b> We found no relationship between menstrual-cycle phase, menopausal status, or use of exogenous progesterone and the occurrence of AMS in trekkers and conclude that hormonal status is not a risk factor for AMS. 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引用次数: 0
摘要
Gardner, Laurel, Linda E. Keyes, Caleb Phillips, Elan Small, Tejaswi Adhikari, Nathan Barott, Ken Zafren, Rony Maharjan, and James Marvel.高海拔地区的女性:月经周期阶段、绝经期和外源性孕酮与急性高山反应无关。00:000-000, 2024.背景:女性体内孕酮水平升高可预防急性登山病(AMS)。荷尔蒙避孕(HC)对急性登山病的影响尚不清楚。我们研究了天然和外源性孕酮对急性登山病发生的影响。研究方法我们对罗布泊(海拔 4940 米)和芒康(海拔 3519 米)的女性徒步旅行者进行了一项前瞻性方便观察研究。我们收集了有关末次月经、使用外源性激素和发生 AMS 的数据。结果共有 1,161 名徒步旅行者符合纳入标准,其中 307 人(26%)患有急性髓系白血病。月经卵泡期(28%)和黄体期(25%)的女性在发生急性膀胱炎方面没有明显差异(P = 0.48)。绝经前(25%)和绝经后(30%)妇女发生急性盆腔炎的比例没有差异(p = 0.33)。使用 HC 不会影响 AMS 的发生(使用 HC 23% 与不使用 HC 26%,p = 0.47),激素替代疗法(HRT)也不会影响 AMS 的发生(使用 HRT 11% 与不使用 HRT 31%,p = 0.13)。结论我们发现月经周期阶段、绝经状态或使用外源性黄体酮与徒步旅行者发生 AMS 之间没有关系,并得出结论:荷尔蒙状态不是发生 AMS 的风险因素。此外,今后的 AMS 研究不应根据荷尔蒙状况将女性排除在外。
Women at Altitude: Menstrual-Cycle Phase, Menopause, and Exogenous Progesterone Are Not Associated with Acute Mountain Sickness.
Gardner, Laurel, Linda E. Keyes, Caleb Phillips, Elan Small, Tejaswi Adhikari, Nathan Barott, Ken Zafren, Rony Maharjan, and James Marvel. Women at altitude: Menstrual-cycle phase, menopause, and exogenous progesterone are not associated with acute mountain sickness. High Alt Med Biol. 00:000-000, 2024. Background: Elevated progesterone levels in women may protect against acute mountain sickness (AMS). The impact of hormonal contraception (HC) on AMS is unknown. We examined the effect of natural and exogenous progesterone on the occurrence of AMS. Methods: We conducted a prospective observational convenience study of female trekkers in Lobuche (4,940 m) and Manang (3,519 m). We collected data on last menstrual period, use of exogenous hormones, and development of AMS. Results: There were 1,161 trekkers who met inclusion criteria, of whom 307 (26%) had AMS. There was no significant difference in occurrence of AMS between women in the follicular (28%) and the luteal (25%) phases of menstruation (p = 0.48). The proportion of premenopausal (25%) versus postmenopausal women (30%) with AMS did not differ (p = 0.33). The use of HC did not influence the occurrence of AMS (HC 23% vs. no HC 26%, p = 0.47), nor did hormonal replacement therapy (HRT) (HRT 11% vs. no HRT 31%, p = 0.13). Conclusion: We found no relationship between menstrual-cycle phase, menopausal status, or use of exogenous progesterone and the occurrence of AMS in trekkers and conclude that hormonal status is not a risk factor for AMS. Furthermore, women should not be excluded from future AMS studies based on hormonal status.
期刊介绍:
High Altitude Medicine & Biology is the only peer-reviewed journal covering the medical and biological issues that impact human life at high altitudes. The Journal delivers critical findings on the impact of high altitude on lung and heart disease, appetite and weight loss, pulmonary and cerebral edema, hypertension, dehydration, infertility, and other diseases. It covers the full spectrum of high altitude life sciences from pathology to human and animal ecology.