COVID-19 患者的 C 端交联端肽水平:前瞻性病例对照研究

IF 2.1 4区 医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL
Mehmet Ali Gul, Nezahat Kurt, Fatma Betul Ozgeris, Neslihan Yuce, Omer Faruk Kocak, Emine Parlak
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引用次数: 0

摘要

背景:冠状病毒病 19(COVID-19)是一种由冠状病毒 2 介导的病毒感染,可导致严重急性呼吸系统综合征(SARS-CoV-2)。该病会影响生化指标和电解质。C端交联端肽(CTX-I)在成熟骨吸收过程中释放,是预测骨吸收的生物标志物:随着大流行病的发展,了解 COVID-19 疾病的影响仍然至关重要。病毒引发的炎症反应会导致骨代谢调节失衡。因此,本研究旨在分析 COVID-19 患者血清中 CTX-I、钙(CA)、磷(P)、镁(Mg)、C 反应蛋白(CRP)和碱性磷酸酶(ALP)的水平,以研究骨吸收与该疾病之间的关系:研究对象包括 56 名 COVID-19 患者(根据疾病严重程度分为轻度、中度和重度亚组)和 25 名健康成人作为对照组。采用酶联免疫吸附试验(ELISA)测定血清 CTX-I 浓度。此外,还使用自动临床化学分析仪测量了 CRP、Ca、Mg、P 和 ALP 水平:结果:COVID-19 患者的血清 CTX-I 水平明显高于对照组(P < 0.05)。结论:COVID-19 患者血清 CTX-I 水平明显高于对照组(P < 0.05):结论:患者组血清 CTX-I 水平的升高导致了 COVID-19 驱动的骨质退化,尽管血清 CTX-I 水平并不因疾病严重程度而异。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
C-terminal cross-linking telopeptide levels in COVID-19 patients: A prospective case-control study.

Background: Coronavirus disease 19 (COVID-19) is a viral infection mediated by coronavirus-2 that causes severe acute respiratory syndrome (SARS-CoV-2). The disease may affect biochemical parameters and electrolytes. C-terminal cross-linking telopeptide (CTX-I) is released during mature bone resorption and is a biomarker for predicting bone resorption.

Objectives: As the pandemic progressed, understanding the effects of COVID-19 disease remained critical. Inflammatory responses triggered by the virus can result in a bone metabolism regulation imbalance. As such, this study aimed to analyze serum levels of CTX-I, calcium (CA), phosphorus (P), magnesium (Mg), C-reactive protein (CRP), and alkaline phosphatase (ALP) in COVID-19 patients to investigate the relationship between bone resorption and the disease.

Material and methods: The study included 56 individuals with COVID-19 (divided into mild, moderate and severe subgroups depending on disease severity) and 25 healthy adults as a control group. Serum CTX-I concentrations were measured with enzyme-linked immunosorbent assay (ELISA). In addition, CRP, Ca, Mg, P, and ALP levels were measured using an automated clinical chemistry analyzer.

Results: Serum CTX-I levels were significantly higher in COVID-19 patients than in the control group (p < 0.05). Furthermore, a positive weak relationship was detected between CRP and CTX-I (r = 0.303, p < 0.05).

Conclusions: Increased serum CTX-I levels in the patient group caused COVID-19-driven bone degradation, though serum CTX-I levels did not differ according to disease severity.

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来源期刊
Advances in Clinical and Experimental Medicine
Advances in Clinical and Experimental Medicine MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
3.70
自引率
4.80%
发文量
153
审稿时长
6-12 weeks
期刊介绍: Advances in Clinical and Experimental Medicine has been published by the Wroclaw Medical University since 1992. Establishing the medical journal was the idea of Prof. Bogumił Halawa, Chair of the Department of Cardiology, and was fully supported by the Rector of Wroclaw Medical University, Prof. Zbigniew Knapik. Prof. Halawa was also the first editor-in-chief, between 1992-1997. The journal, then entitled "Postępy Medycyny Klinicznej i Doświadczalnej", appeared quarterly. Prof. Leszek Paradowski was editor-in-chief from 1997-1999. In 1998 he initiated alterations in the profile and cover design of the journal which were accepted by the Editorial Board. The title was changed to Advances in Clinical and Experimental Medicine. Articles in English were welcomed. A number of outstanding representatives of medical science from Poland and abroad were invited to participate in the newly established International Editorial Staff. Prof. Antonina Harłozińska-Szmyrka was editor-in-chief in years 2000-2005, in years 2006-2007 once again prof. Leszek Paradowski and prof. Maria Podolak-Dawidziak was editor-in-chief in years 2008-2016. Since 2017 the editor-in chief is prof. Maciej Bagłaj. Since July 2005, original papers have been published only in English. Case reports are no longer accepted. The manuscripts are reviewed by two independent reviewers and a statistical reviewer, and English texts are proofread by a native speaker. The journal has been indexed in several databases: Scopus, Ulrich’sTM International Periodicals Directory, Index Copernicus and since 2007 in Thomson Reuters databases: Science Citation Index Expanded i Journal Citation Reports/Science Edition. In 2010 the journal obtained Impact Factor which is now 1.179 pts. Articles published in the journal are worth 15 points among Polish journals according to the Polish Committee for Scientific Research and 169.43 points according to the Index Copernicus. Since November 7, 2012, Advances in Clinical and Experimental Medicine has been indexed and included in National Library of Medicine’s MEDLINE database. English abstracts printed in the journal are included and searchable using PubMed http://www.ncbi.nlm.nih.gov/pubmed.
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