Marta Díaz-Navarro, Rama Hafian, María Jesús Pérez-Granda, Emilia Cercenado, Patricia Muñoz, María Guembe
{"title":"解决导管锁定疗法:肝素与达巴万星一起在溶液中冷冻时是否会降低达巴万星的生物活性?","authors":"Marta Díaz-Navarro, Rama Hafian, María Jesús Pérez-Granda, Emilia Cercenado, Patricia Muñoz, María Guembe","doi":"10.1016/j.eimc.2024.02.005","DOIUrl":null,"url":null,"abstract":"The possible use of dalbavancin as a catheter lock solution was previously demonstrated by our study group. However, it was needed to assess whether heparin could affect dalbavancin bioactivity during freezing storage. We tested the bioactivity of a dalbavancin+heparin (DH) vs. dalbavancin () against Staphylococcal biofilms comparing DH median value of cfu counts and metabolic activity with that obtained for before and during storage under freezing up to 6 months. Despite there was a slight decrease in the median percentage reduction of metabolic activity at month 3 in between DH and (97.6 vs. 100, =0.037), considering the clinical criteria, no significant reduction in any of the variables tested was observed at the end of the experiment between and DH solutions. The addition of heparin to a dalbavancin lock solution did not affect its bioactivity against staphylococcal biofilms irrespective of its preservation time under freezing.","PeriodicalId":501441,"journal":{"name":"Enfermedades Infecciosas y Microbiología Clínica","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2024-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Addressing catheter lock therapy: Does heparin reduce the bioactivity of dalbavancin when together in solution during freezing?\",\"authors\":\"Marta Díaz-Navarro, Rama Hafian, María Jesús Pérez-Granda, Emilia Cercenado, Patricia Muñoz, María Guembe\",\"doi\":\"10.1016/j.eimc.2024.02.005\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The possible use of dalbavancin as a catheter lock solution was previously demonstrated by our study group. However, it was needed to assess whether heparin could affect dalbavancin bioactivity during freezing storage. We tested the bioactivity of a dalbavancin+heparin (DH) vs. dalbavancin () against Staphylococcal biofilms comparing DH median value of cfu counts and metabolic activity with that obtained for before and during storage under freezing up to 6 months. Despite there was a slight decrease in the median percentage reduction of metabolic activity at month 3 in between DH and (97.6 vs. 100, =0.037), considering the clinical criteria, no significant reduction in any of the variables tested was observed at the end of the experiment between and DH solutions. The addition of heparin to a dalbavancin lock solution did not affect its bioactivity against staphylococcal biofilms irrespective of its preservation time under freezing.\",\"PeriodicalId\":501441,\"journal\":{\"name\":\"Enfermedades Infecciosas y Microbiología Clínica\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-03-14\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Enfermedades Infecciosas y Microbiología Clínica\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1016/j.eimc.2024.02.005\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Enfermedades Infecciosas y Microbiología Clínica","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1016/j.eimc.2024.02.005","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Addressing catheter lock therapy: Does heparin reduce the bioactivity of dalbavancin when together in solution during freezing?
The possible use of dalbavancin as a catheter lock solution was previously demonstrated by our study group. However, it was needed to assess whether heparin could affect dalbavancin bioactivity during freezing storage. We tested the bioactivity of a dalbavancin+heparin (DH) vs. dalbavancin () against Staphylococcal biofilms comparing DH median value of cfu counts and metabolic activity with that obtained for before and during storage under freezing up to 6 months. Despite there was a slight decrease in the median percentage reduction of metabolic activity at month 3 in between DH and (97.6 vs. 100, =0.037), considering the clinical criteria, no significant reduction in any of the variables tested was observed at the end of the experiment between and DH solutions. The addition of heparin to a dalbavancin lock solution did not affect its bioactivity against staphylococcal biofilms irrespective of its preservation time under freezing.