芪冬藿香汤治疗急性肺损伤和急性呼吸窘迫综合征的有效性和安全性:随机对照试验。

Y U Zhengqiu, Y U Liuda, Chen Ye, L I Mingjing, Cai Wanru
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引用次数: 0

摘要

目的评估祁东藿香正气水辅助治疗急性肺损伤和急性呼吸窘迫综合征(ALI/ARDS)的疗效:方法:本院内科重症监护室收治的急性肺损伤/急性呼吸窘迫综合征患者被随机分配到对照组或 QDHX 组,接受标准治疗。QDHX组通过口服或胃管接受QDHX(每天50毫升,共14天)治疗。主要结果根据中医综合征评分进行测量,氧分压/吸入氧分压(PaO2/FiO2)水平作为次要结果:共有 73 名患者完成了研究(中医组 36 人,常规组 37 人),并对他们的病历进行了分析。治疗 14 天后,中医组的中医综合征评分显著下降(P 0.05),PaO2/FiO2 水平显著升高(P 0.05)。中西医结合治疗效果比单纯西医治疗效果更显著。未观察到严重的副作用:我们的研究结果表明,QDHX 联合常规药物治疗可明显减轻 ALI/ARDS 患者的一些临床症状。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effectiveness and safety of Qidong Huoxue decoction in treatment of acute lung injury and acute respiratory distress syndrome: a randomized, controlled trial.

Objective: To evaluate the efficacy of Qidong Huoxue decoction (,QDHX) in treating acute lung injury and acute respiratory distress syndrome (ALI/ARDS) when used as an adjunctive treatment.

Methods: ALI/ARDS patients admitted to our medical intensive care unit were randomly allocated to the control group or the QDHX group and received standard therapy. The QDHX group received QDHX (50 mL per day for 14 d) orally or via a gastric tube. The primary outcome was measured according to Traditional Chinese Medicine (TCM) syndrome scores, with partial pressure of oxygen/fraction of inspired oxygen (PaO2/FiO2) levels as the secondary outcome.

Results: A total of 73 patients completed the study (36 in the TCM and 37 in the conventional group), and their records were analyzed. After 14-d treatment, the TCM group showed a significant decrease in TCM syndrome scores (P < 0.05) and increased PaO2/FiO2 levels (P < 0.05). The therapeutic effect of integrated Chinese and western medicine was more significant than that of Western Medicine alone. No serious side effects were observed.

Conclusions: Our study results show that QDHX in combination with conventional drug therapy can significantly reduce some clinical symptoms in patients with ALI/ARDS.

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