Jean A. Boutin , Valérie Hamon de Almeida , Nathalie Coussay , Céline Legros , Gilles Ferry , Karine Reybier
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Melatonin facts: Melatonin lacks immuno-inflammation boosting capacities at the molecular and cellular levels
Among the properties melatonin is claimed to possess, are the immuno-inflammation inductive capacities that would be responsible of some of the paramount of activities melatonin is reported to have in most of the human pathological conditions. In the present paper, we measured the effect of melatonin on established cellular models of immuno-inflammation, and found none. The discrepancies are discussed, especially because those properties are reported at pharmacological concentration (1 μM and beyond) at which the melatonin receptors are desensitized by internalization, leading to putative non-receptor-dependent mechanism of action.
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