运动训练对成年艾滋病病毒感染者骨骼健康的影响:系统综述与荟萃分析。

IF 1.2 4区 医学 Q4 HEALTH POLICY & SERVICES
Karynne Grutter Lopes, Gabriela Andrade Paz, Paulo Farinatti, Juliana Pereira Borges
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引用次数: 0

摘要

我们研究了运动训练对人类免疫缺陷病毒感染者(PLHIV)骨矿物质密度(BMD)的影响。我们在 Pubmed、Scopus、Cochrane Library 和 ScienceDirect 数据库中搜索了通过双能 X 射线吸收测定法(DXA)评估的基线与干预后情况,研究运动训练对人类免疫缺陷病毒感染者(PLHIV)骨矿物质密度(BMD)诱导变化的试验。计算对冲效应大小 (ES) 时考虑了 BMD 变化假设的固定效应。对于有一个以上干预或 BMD 评估部位的试验,进行了分类比较。七项试验包括 210 名艾滋病毒感染者和 35 名非艾滋病毒感染者对照组。方法学质量采用物理治疗证据数据库(PEDro)量表进行评估,从较差到中等不等。干预采用了孤立阻力运动、有氧运动和阻力运动相结合的运动方案,以及多模式运动方案,每周 3 天,持续 12-10 周。其中一项对照试验和另一项非对照试验效果显著,股骨颈和总股骨得到改善(ES 分别为 2.14 和 0.49)。这些特定 ES 的大小影响了总体效果(对照和非对照试验),总体效果很小,但很显著(k = 12,ES 0.277,95% 置信区间 0.120-0.434)。阻力训练可促进 PLHIV BMD 的良好适应,尤其是股骨。未来的研究应阐明最佳剂量-反应关系以及运动诱导 PLHIV BMD 适应性的生理机制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effects of exercise training on bone health in adults living with HIV: a systematic review with meta-analysis.

We investigated the effects of exercise training on bone mineral density (BMD) in people living with Human Immunodeficiency Virus (PLHIV). Pubmed, Scopus, Cochrane Library, and ScienceDirect databases were searched for trials investigating exercise training-induced changes in BMD of PLHIV at baseline vs. post-intervention assessed by dual-energy X-ray absorptiometry (DXA). Hedge effect sizes (ES) were calculated incorporating fixed effects for BMD variation assumptions. Disaggregated comparisons were performed for trials with more than one intervention or BMD site assessment. Seven trials included 210 PLHIV and 35 non-HIV-infected controls. Methodological quality evaluated using the Physiotherapy Evidence Database (PEDro) scale ranged from poor to moderate. Interventions applied isolated resistance, combined aerobic and resistance, and multimodal exercise protocols performed 3 d/wk for 12-to 104 week. One controlled and another uncontrolled trial presented significant effects, reporting improvements at the femoral neck and total (ES 2.14 and 0.49, respectively). Magnitude of those specific ES influenced the overall effect (controlled and uncontrolled trials), which was small but significant (k = 12, ES 0.277, 95% confidence interval 0.120-0.434). Resistance training may promote favorable adaptations in BMD of PLHIV, particularly in femur. Future research should elucidate the optimal dose-response relationship and physiological mechanisms underlying exercise-induced adaptations on the BMD of PLHIV.

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CiteScore
3.50
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172
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