铁耗竭对弓形虫菌株的生长和存活有不同的影响。

IF 5.5 1区 农林科学 Q1 IMMUNOLOGY
Virulence Pub Date : 2024-12-01 Epub Date: 2024-03-20 DOI:10.1080/21505594.2024.2329566
Eléa A Renaud, Ambre J M Maupin, Yann Bordat, Arnault Graindorge, Laurence Berry, Sébastien Besteiro
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引用次数: 0

摘要

弓形虫(Toxoplasma gondii)是一种细胞内寄生虫,主要影响免疫力低下的人和发育中的胎儿,是一种称为弓形虫病的病原体。寄生虫可以从宿主身上获取必需的营养物质,以支持其生长和生存。其中,铁是维持细胞基本功能所需的最重要元素之一,因为它参与了许多关键的新陈代谢过程,包括氧气运输、氧化还原平衡和电子传递。我们评估了铁螯合剂对几种寄生虫菌株生长发育的影响,发现它们耐受铁耗竭的能力各不相同。通常与急性弓形虫病模型相关的寄生虫的生长受到铁耗竭的强烈影响,而囊原性菌株则不太敏感,因为它们能够转化为与慢性疾病相关的持续发育型。关于铁耗竭对寄生虫影响的超微结构和生物化学特征描述也突显了寄生虫和宿主新陈代谢的显著变化,脂滴明显累积,脂质平衡受到干扰。总之,我们的研究表明,虽然急性铁耗竭对淋病双球菌的生长有重要影响,但它对活跃分裂的寄生虫的影响更为深远,而新陈代谢不太活跃的寄生虫形式可能能够避免一些最有害的后果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Iron depletion has different consequences on the growth and survival of Toxoplasma gondii strains.

Toxoplasma gondii is an obligate intracellular parasite responsible for a pathology called toxoplasmosis, which primarily affects immunocompromised individuals and developing foetuses. The parasite can scavenge essential nutrients from its host to support its growth and survival. Among them, iron is one of the most important elements needed to sustain basic cellular functions as it is involved in a number of key metabolic processes, including oxygen transport, redox balance, and electron transport. We evaluated the effects of an iron chelator on the development of several parasite strains and found that they differed in their ability to tolerate iron depletion. The growth of parasites usually associated with a model of acute toxoplasmosis was strongly affected by iron depletion, whereas cystogenic strains were less sensitive as they were able to convert into persisting developmental forms that are associated with the chronic form of the disease. Ultrastructural and biochemical characterization of the impact of iron depletion on parasites also highlighted striking changes in both their metabolism and that of the host, with a marked accumulation of lipid droplets and perturbation of lipid homoeostasis. Overall, our study demonstrates that although acute iron depletion has an important effect on the growth of T. gondii, it has a more profound impact on actively dividing parasites, whereas less metabolically active parasite forms may be able to avoid some of the most detrimental consequences.

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来源期刊
Virulence
Virulence IMMUNOLOGY-MICROBIOLOGY
CiteScore
9.20
自引率
1.90%
发文量
123
审稿时长
6-12 weeks
期刊介绍: Virulence is a fully open access peer-reviewed journal. All articles will (if accepted) be available for anyone to read anywhere, at any time immediately on publication. Virulence is the first international peer-reviewed journal of its kind to focus exclusively on microbial pathogenicity, the infection process and host-pathogen interactions. To address the new infectious challenges, emerging infectious agents and antimicrobial resistance, there is a clear need for interdisciplinary research.
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