关于二尖瓣脱垂人群中的室性心律失常和心脏性猝死预测,我们目前了解多少?生物标记物能否帮助我们预测其发生?

IF 3.1 3区 医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS
Current Cardiology Reports Pub Date : 2024-05-01 Epub Date: 2024-03-20 DOI:10.1007/s11886-024-02030-9
D Dziadosz, L Daniłowicz-Szymanowicz, P Wejner-Mik, M Budnik, B Brzezińska, P Duchnowski, K Golińska-Grzybała, K Jaworski, I Jedliński, M Kamela, J Kasprzak, M Kowalczyk-Domagała, K Kurnicka, D Kustrzycka-Kratochwil, K Mickiewicz, O Możeńska, Z Oko-Sarnowska, M Plewka, A Polewczyk, B Uziębło-Życzkowska, K Wierzbowska-Drabik, R Wachnicka-Truty, E Wołoszyn-Horák, P Szymański, A Gackowski, K Mizia-Stec
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引用次数: 0

摘要

综述的目的:总结有关二尖瓣脱垂(MVP)及其与房性和室性心律失常发生的相关性的现有数据。评估几种诊断方法的预后价值,如经胸超声心动图、经食道超声心动图、心脏磁共振、心脏计算机断层扫描、心电图和有关心律失常发作的电生理学。探索心血管系统细胞内外的生物化学及其生物标志物,作为预测 MVP 患者心律紊乱的诊断工具:MVP 是一种常见的、主要是良性的瓣膜疾病。其发病率占总人口的 2-3%。MVP 是一种异质性和高度可变的现象,有三种结构表型:肌瘤变性、纤维弹性缺乏和畸形。运动不耐受、室上性心动过速和胸部不适等症状通常与心身因素有关。虽然 MVP 被认为是良性的,但已观察到孤立的 MVP(无二尖瓣反流(MR)或左心室功能障碍)与室性心律失常(VA)和心脏性猝死(SCD)之间存在关联。MVP 患者的 SCD 发病率约为每年 0.6%,是普通人群的 6 倍。MVP 患者通常无症状,这给筛查 VA 和预防 SCD 带来了挑战。因此,利用影像诊断、生化和基因筛查等各种工具仔细评估 MVP 患者的 VA 和 SCD 风险至关重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

What Do We Know So Far About Ventricular Arrhythmias and Sudden Cardiac Death Prediction in the Mitral Valve Prolapse Population? Could Biomarkers Help Us Predict Their Occurrence?

What Do We Know So Far About Ventricular Arrhythmias and Sudden Cardiac Death Prediction in the Mitral Valve Prolapse Population? Could Biomarkers Help Us Predict Their Occurrence?

Purpose of the review: To summarize currently available data on the topic of mitral valve prolapse (MVP) and its correlation to the occurrence of atrial and ventricular arrhythmias. To assess the prognostic value of several diagnostic methods such as transthoracic echocardiography, transesophageal echocardiography, cardiac magnetic resonance, cardiac computed tomography, electrocardiography, and electrophysiology concerning arrhythmic episodes. To explore intra and extracellular biochemistry of the cardiovascular system and its biomarkers as diagnostic tools to predict rhythm disturbances in the MVP population.

Recent findings: MVP is a common and mainly benign valvular disorder. It affects 2-3% of the general population. MVP is a heterogeneous and highly variable phenomenon with three structural phenotypes: myxomatous degeneration, fibroelastic deficiency, and forme fruste. Exercise intolerance, supraventricular tachycardia, and chest discomfort are the symptoms that are often paired with psychosomatic components. Though MVP is thought to be benign, the association between isolated MVP without mitral regurgitation (MR) or left ventricle dysfunction, with ventricular arrhythmia (VA) and sudden cardiac death (SCD) has been observed. The incidence of SCD in the MVP population is around 0.6% per year, which is 6 times higher than the occurrence of SCD in the general population. Often asymptomatic MVP population poses a challenge to screen for VA and prevent SCD. Therefore, it is crucial to carefully assess the risk of VA and SCD in patients with MVP with the use of various tools such as diagnostic imaging and biochemical and genetic screening.

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来源期刊
Current Cardiology Reports
Current Cardiology Reports CARDIAC & CARDIOVASCULAR SYSTEMS-
CiteScore
6.20
自引率
2.70%
发文量
209
期刊介绍: The aim of this journal is to provide timely perspectives from experts on current advances in cardiovascular medicine. We also seek to provide reviews that highlight the most important recently published papers selected from the wealth of available cardiovascular literature. We accomplish this aim by appointing key authorities in major subject areas across the discipline. Section editors select topics to be reviewed by leading experts who emphasize recent developments and highlight important papers published over the past year. An Editorial Board of internationally diverse members suggests topics of special interest to their country/region and ensures that topics are current and include emerging research. We also provide commentaries from well-known figures in the field.
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