L. N. Shishkina, D. V. Paramonov, M. A. Klimovich, M. V. Kozlov
{"title":"卵磷脂脂质体的理化性质和组成取决于其形成条件","authors":"L. N. Shishkina, D. V. Paramonov, M. A. Klimovich, M. V. Kozlov","doi":"10.1134/S0006350923060179","DOIUrl":null,"url":null,"abstract":"<p>The influence of the composition and physicochemical properties of lecithin lipids, the duration of exposure to ultrasound, and centrifugation on the composition and physicochemical properties of liposomes formed from lecithin has been studied. It has been revealed that the intensity of lipid peroxidation has an inverse correlation with the phospholipid level in the total lipid composition of lecithin and a direct correlation with the relative content of cardiolipin in the composition of lecithin phospholipids. It has been shown that the duration of ultrasound exposure and centrifugation causes changes in the composition and properties of the liposome lipids. Decreases in the pH of the medium and the intensity of lipid peroxidation of liposomes were observed under centrifugation. It was revealed that the changes in the ability of the liposome lipids to oxidation depending on the duration of ultrasound exposure and centrifugation are due to the relative changes in the sum percentage of the acidic minor fractions in the composition of their phospholipids.</p>","PeriodicalId":493,"journal":{"name":"Biophysics","volume":"68 6","pages":"971 - 977"},"PeriodicalIF":4.0330,"publicationDate":"2024-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The Physicochemical Properties and Composition of Liposome Lipids from Lecithin Depending on the Conditions of Their Formation\",\"authors\":\"L. N. Shishkina, D. V. Paramonov, M. A. Klimovich, M. V. Kozlov\",\"doi\":\"10.1134/S0006350923060179\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>The influence of the composition and physicochemical properties of lecithin lipids, the duration of exposure to ultrasound, and centrifugation on the composition and physicochemical properties of liposomes formed from lecithin has been studied. It has been revealed that the intensity of lipid peroxidation has an inverse correlation with the phospholipid level in the total lipid composition of lecithin and a direct correlation with the relative content of cardiolipin in the composition of lecithin phospholipids. It has been shown that the duration of ultrasound exposure and centrifugation causes changes in the composition and properties of the liposome lipids. Decreases in the pH of the medium and the intensity of lipid peroxidation of liposomes were observed under centrifugation. It was revealed that the changes in the ability of the liposome lipids to oxidation depending on the duration of ultrasound exposure and centrifugation are due to the relative changes in the sum percentage of the acidic minor fractions in the composition of their phospholipids.</p>\",\"PeriodicalId\":493,\"journal\":{\"name\":\"Biophysics\",\"volume\":\"68 6\",\"pages\":\"971 - 977\"},\"PeriodicalIF\":4.0330,\"publicationDate\":\"2024-03-18\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Biophysics\",\"FirstCategoryId\":\"4\",\"ListUrlMain\":\"https://link.springer.com/article/10.1134/S0006350923060179\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"Biochemistry, Genetics and Molecular Biology\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biophysics","FirstCategoryId":"4","ListUrlMain":"https://link.springer.com/article/10.1134/S0006350923060179","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Biochemistry, Genetics and Molecular Biology","Score":null,"Total":0}
The Physicochemical Properties and Composition of Liposome Lipids from Lecithin Depending on the Conditions of Their Formation
The influence of the composition and physicochemical properties of lecithin lipids, the duration of exposure to ultrasound, and centrifugation on the composition and physicochemical properties of liposomes formed from lecithin has been studied. It has been revealed that the intensity of lipid peroxidation has an inverse correlation with the phospholipid level in the total lipid composition of lecithin and a direct correlation with the relative content of cardiolipin in the composition of lecithin phospholipids. It has been shown that the duration of ultrasound exposure and centrifugation causes changes in the composition and properties of the liposome lipids. Decreases in the pH of the medium and the intensity of lipid peroxidation of liposomes were observed under centrifugation. It was revealed that the changes in the ability of the liposome lipids to oxidation depending on the duration of ultrasound exposure and centrifugation are due to the relative changes in the sum percentage of the acidic minor fractions in the composition of their phospholipids.
BiophysicsBiochemistry, Genetics and Molecular Biology-Biophysics
CiteScore
1.20
自引率
0.00%
发文量
67
期刊介绍：
Biophysics is a multidisciplinary international peer reviewed journal that covers a wide scope of problems related to the main physical mechanisms of processes taking place at different organization levels in biosystems. It includes structure and dynamics of macromolecules, cells and tissues; the influence of environment; energy transformation and transfer; thermodynamics; biological motility; population dynamics and cell differentiation modeling; biomechanics and tissue rheology; nonlinear phenomena, mathematical and cybernetics modeling of complex systems; and computational biology. The journal publishes short communications devoted and review articles.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
