在评估阴道微环境对人类乳头瘤病毒感染变化状态的反应方面，代谢特征优于微生物群

IF 7.8 1区生物学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

npj Biofilms and Microbiomes Pub Date : 2024-03-20 DOI:10.1038/s41522-024-00500-0

Wenkui Dai, Hui Du, Qian Zhou, Sumei Li, Yinan Wang, Jun Hou, Chunlei Guo, Qing Yang, Changzhong Li, Shouxia Xie, Shuai Cheng Li, Ruifang Wu

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引用次数: 0

摘要

基于人群的研究缺乏对 HPV 感染对阴道微环境影响的调查，而阴道微环境会影响 HPV 持续感染的风险。这项前瞻性研究旨在揭示阴道微生物群（VM）和阴道代谢组在HPV感染状态改变时的动态变化。我们的研究结果表明，在评估HPV状态改变对阴道微环境的影响时，阴道代谢组可能是优于VM的指标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Metabolic profiles outperform the microbiota in assessing the response of vaginal microenvironments to the changed state of HPV infection

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Metabolic profiles outperform the microbiota in assessing the response of vaginal microenvironments to the changed state of HPV infection

There is a deficiency in population-based studies investigating the impact of HPV infection on vaginal microenvironment, which influences the risk of persistent HPV infection. This prospective study aimed to unravel the dynamics of vaginal microbiota (VM) and vaginal metabolome in reaction to the changed state of HPV infection. Our results propose that the vaginal metabolome may be a superior indicator to VM when assessing the impact of altered HPV state on the vaginal microenvironment.

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来源期刊

npj Biofilms and Microbiomes Immunology and Microbiology-Microbiology

CiteScore

12.10

自引率

3.30%

发文量

审稿时长

9 weeks

期刊介绍： npj Biofilms and Microbiomes is a comprehensive platform that promotes research on biofilms and microbiomes across various scientific disciplines. The journal facilitates cross-disciplinary discussions to enhance our understanding of the biology, ecology, and communal functions of biofilms, populations, and communities. It also focuses on applications in the medical, environmental, and engineering domains. The scope of the journal encompasses all aspects of the field, ranging from cell-cell communication and single cell interactions to the microbiomes of humans, animals, plants, and natural and built environments. The journal also welcomes research on the virome, phageome, mycome, and fungome. It publishes both applied science and theoretical work. As an open access and interdisciplinary journal, its primary goal is to publish significant scientific advancements in microbial biofilms and microbiomes. The journal enables discussions that span multiple disciplines and contributes to our understanding of the social behavior of microbial biofilm populations and communities, and their impact on life, human health, and the environment.