Manganese Iron Oxide Nanoparticles for Magnetic Hyperthermia, Antibacterial and ROS Generation Performance

The preparation of manganese substituted iron oxide magnetic nanoparticles by polyol synthesis route. Due to the unique properties, diethylene glycol (DEG) and tri-ethylene glycol (TEG) used as a solvent in synthesis method with different volumetric variations. The structural, morphological and hyperthermic properties of prepared samples are investigated. Formation of single-phase cubic spinel lattice for all compositions confirmed by X-ray diffraction and crystallite size was found to be decreased from 20.6 ± 1.3 to 15.2 ± 1.7 nm with varying ratio of DEG/TEG. Transmission electron microscopy (TEM) analysis displayed spherical grains with an agglomeration of the MnFe₂O₄ magnetic nanoparticles (MNPs). Heating ability of MNPs studied with an induction heating system under different magnetic field strengths at 20 kA/m and 26.6 kA/m by varying nanoparticle concentrations at fixed frequency of 278 kHz. Antimicrobial activity on E. coli and antifungal activity on C. albicans showed effectiveness of MNPs at 10 mg/mL for such activities. Additionally, ROS induction in presence of MNPs illustrates probable action against E. coli and C. albicans and as antibacterial and antifungal agent in the medical field due to ROS generation ability.It has been shown that these optimized MNPs will play multifaceted roles for magnetic hyperthermia therapy as heat mediators, and antibacterial/antifungal agents owing to their magnetic induction heating properties and biological activities.