{"title":"生酮饮食作为癌症治疗和预防策略:一种治疗方法","authors":"Neha Ph.D. , Rishabh Chaudhary Ph.D.","doi":"10.1016/j.nut.2024.112427","DOIUrl":null,"url":null,"abstract":"<div><p>Cancer remains a significant global health problem, contributing substantially to morbidity and mortality rates. While traditional treatments like surgery, chemotherapy, and radiation therapy are mainstays in cancer care, their efficacy as standalone modalities is often limited. Consequently, there is a growing interest in novel approaches that may enhance therapeutic outcomes. Over recent years, both preclinical and clinical investigations have highlighted the potential of the ketogenic diet as a complementary strategy in cancer treatment. The ketogenic diet, characterized by low carbohydrate, high fat, and moderate protein intake, has emerged as a promising avenue for augmenting the efficacy of conventional therapies by altering the metabolic dynamics of cancer cells. Research suggests that integrating the ketogenic diet with standard treatment protocols may enhance the antitumor effects of chemotherapy, improve treatment tolerability, and enhance overall quality of life. This review aims to elucidate the underlying mechanisms that drive the purported anticancer properties of the ketogenic diet. By inducing a metabolic state characterized by ketosis, the diet creates an unfavorable metabolic environment for cancerous cells, potentially hindering their growth and proliferation. Through a comprehensive analysis of preclinical and clinical data, this review aims to explain the therapeutic potential of the ketogenic diet as an adjunctive treatment strategy in cancer. Understanding the metabolic underpinnings of the ketogenic diet and its impact on tumor biology is essential for optimizing its clinical utility and informing treatment decisions. By exploring the synergistic interactions between the ketogenic diet and conventional therapies, clinicians and researchers may reveal new avenues for improving cancer care and outcomes.</p></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":null,"pages":null},"PeriodicalIF":3.2000,"publicationDate":"2024-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Ketogenic diet as a treatment and prevention strategy for cancer: A therapeutic alternative\",\"authors\":\"Neha Ph.D. , Rishabh Chaudhary Ph.D.\",\"doi\":\"10.1016/j.nut.2024.112427\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Cancer remains a significant global health problem, contributing substantially to morbidity and mortality rates. While traditional treatments like surgery, chemotherapy, and radiation therapy are mainstays in cancer care, their efficacy as standalone modalities is often limited. Consequently, there is a growing interest in novel approaches that may enhance therapeutic outcomes. Over recent years, both preclinical and clinical investigations have highlighted the potential of the ketogenic diet as a complementary strategy in cancer treatment. The ketogenic diet, characterized by low carbohydrate, high fat, and moderate protein intake, has emerged as a promising avenue for augmenting the efficacy of conventional therapies by altering the metabolic dynamics of cancer cells. Research suggests that integrating the ketogenic diet with standard treatment protocols may enhance the antitumor effects of chemotherapy, improve treatment tolerability, and enhance overall quality of life. This review aims to elucidate the underlying mechanisms that drive the purported anticancer properties of the ketogenic diet. By inducing a metabolic state characterized by ketosis, the diet creates an unfavorable metabolic environment for cancerous cells, potentially hindering their growth and proliferation. Through a comprehensive analysis of preclinical and clinical data, this review aims to explain the therapeutic potential of the ketogenic diet as an adjunctive treatment strategy in cancer. Understanding the metabolic underpinnings of the ketogenic diet and its impact on tumor biology is essential for optimizing its clinical utility and informing treatment decisions. By exploring the synergistic interactions between the ketogenic diet and conventional therapies, clinicians and researchers may reveal new avenues for improving cancer care and outcomes.</p></div>\",\"PeriodicalId\":19482,\"journal\":{\"name\":\"Nutrition\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":3.2000,\"publicationDate\":\"2024-03-16\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nutrition\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0899900724000777\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"NUTRITION & DIETETICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nutrition","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0899900724000777","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"NUTRITION & DIETETICS","Score":null,"Total":0}
Ketogenic diet as a treatment and prevention strategy for cancer: A therapeutic alternative
Cancer remains a significant global health problem, contributing substantially to morbidity and mortality rates. While traditional treatments like surgery, chemotherapy, and radiation therapy are mainstays in cancer care, their efficacy as standalone modalities is often limited. Consequently, there is a growing interest in novel approaches that may enhance therapeutic outcomes. Over recent years, both preclinical and clinical investigations have highlighted the potential of the ketogenic diet as a complementary strategy in cancer treatment. The ketogenic diet, characterized by low carbohydrate, high fat, and moderate protein intake, has emerged as a promising avenue for augmenting the efficacy of conventional therapies by altering the metabolic dynamics of cancer cells. Research suggests that integrating the ketogenic diet with standard treatment protocols may enhance the antitumor effects of chemotherapy, improve treatment tolerability, and enhance overall quality of life. This review aims to elucidate the underlying mechanisms that drive the purported anticancer properties of the ketogenic diet. By inducing a metabolic state characterized by ketosis, the diet creates an unfavorable metabolic environment for cancerous cells, potentially hindering their growth and proliferation. Through a comprehensive analysis of preclinical and clinical data, this review aims to explain the therapeutic potential of the ketogenic diet as an adjunctive treatment strategy in cancer. Understanding the metabolic underpinnings of the ketogenic diet and its impact on tumor biology is essential for optimizing its clinical utility and informing treatment decisions. By exploring the synergistic interactions between the ketogenic diet and conventional therapies, clinicians and researchers may reveal new avenues for improving cancer care and outcomes.
期刊介绍:
Nutrition has an open access mirror journal Nutrition: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review.
Founded by Michael M. Meguid in the early 1980''s, Nutrition presents advances in nutrition research and science, informs its readers on new and advancing technologies and data in clinical nutrition practice, encourages the application of outcomes research and meta-analyses to problems in patient-related nutrition; and seeks to help clarify and set the research, policy and practice agenda for nutrition science to enhance human well-being in the years ahead.