少突胶质细胞分化的调节因子

IF 6.9 2区 生物学 Q1 CELL BIOLOGY
Ben Emery, Teresa L. Wood
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引用次数: 0

摘要

髓鞘化是一种确保神经冲动沿着轴突快速有效传播的进化机制。在中枢神经系统(CNS)中,髓鞘化是由高度特化的神经胶质细胞--少突胶质细胞完成的。髓鞘的形成是中枢神经系统发育过程中一个漫长的环节,在人类成年后仍会继续进行,以应对损伤或作为神经可塑性的一个组成部分。髓鞘形成的时间与少突胶质细胞的产生密切相关,少突胶质细胞的祖细胞--少突胶质细胞前体细胞(OPCs)的分化贯穿整个发育中和成年的中枢神经系统。在这篇文章中,我们总结了目前对调控少突胶质细胞前体细胞分化并进而调控中枢神经系统轴突髓鞘化的一些信号和途径的理解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Regulators of Oligodendrocyte Differentiation
Myelination has evolved as a mechanism to ensure fast and efficient propagation of nerve impulses along axons. Within the central nervous system (CNS), myelination is carried out by highly specialized glial cells, oligodendrocytes. The formation of myelin is a prolonged aspect of CNS development that occurs well into adulthood in humans, continuing throughout life in response to injury or as a component of neuroplasticity. The timing of myelination is tightly tied to the generation of oligodendrocytes through the differentiation of their committed progenitors, oligodendrocyte precursor cells (OPCs), which reside throughout the developing and adult CNS. In this article, we summarize our current understanding of some of the signals and pathways that regulate the differentiation of OPCs, and thus the myelination of CNS axons.
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来源期刊
CiteScore
15.00
自引率
1.40%
发文量
56
审稿时长
3-8 weeks
期刊介绍: Cold Spring Harbor Perspectives in Biology offers a comprehensive platform in the molecular life sciences, featuring reviews that span molecular, cell, and developmental biology, genetics, neuroscience, immunology, cancer biology, and molecular pathology. This online publication provides in-depth insights into various topics, making it a valuable resource for those engaged in diverse aspects of biological research.
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