衰老过程中的排泄过程：与衰老相关疾病的支持性证据、机制和治疗前景。

IF 11.4 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Journal of Advanced Research Pub Date : 2025-03-01 DOI:10.1016/j.jare.2024.03.008

Meng Zhang , Jin Wei , Yu Sun , Chang He , Shiyin Ma , Xudong Pan , Xiaoyan Zhu

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引用次数: 0

摘要

背景：衰老的特点是在外部和内部因素的共同作用下，损伤不断累积。衰老会对吞噬细胞产生不同的影响，其中包括流出细胞功能受损。吞噬细胞的排出能力不足可导致慢性炎症、衰老和其他一些临床疾病：我们的综述强调了在各种老年相关疾病中使用双靶点的可行性和广泛性，以减少老年相关疾病的发生和进展，最终促进健康老龄化和延长寿命。综述的主要科学概念因此，同时实施旨在增强功效细胞机制和抗衰老治疗的策略，有可能成为延长健康寿命的有效干预措施。在这篇综述中，我们全面讨论了流出细胞的概念和生理效应。随后，我们研究了流出细胞与衰老特征之间的关联。最后，我们讨论了与衰老相关疾病的治疗干预方面越来越多的证据，重点是衰老和细胞外分泌的生理过程。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

The efferocytosis process in aging: Supporting evidence, mechanisms, and therapeutic prospects for age-related diseases

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The efferocytosis process in aging: Supporting evidence, mechanisms, and therapeutic prospects for age-related diseases

Background

Aging is characterized by an ongoing struggle between the buildup of damage caused by a combination of external and internal factors. Aging has different effects on phagocytes, including impaired efferocytosis. A deficiency in efferocytosis can cause chronic inflammation, aging, and several other clinical disorders.

Aim of review

Our review underscores the possible feasibility and extensive scope of employing dual targets in various age-related diseases to reduce the occurrence and progression of age-related diseases, ultimately fostering healthy aging and increasing lifespan.

Key scientific concepts of review

Hence, the concurrent implementation of strategies aimed at augmenting efferocytic mechanisms and anti-aging treatments has the potential to serve as a potent intervention for extending the duration of a healthy lifespan. In this review, we comprehensively discuss the concept and physiological effects of efferocytosis. Subsequently, we investigated the association between efferocytosis and the hallmarks of aging. Finally, we discuss growing evidence regarding therapeutic interventions for age-related disorders, focusing on the physiological processes of aging and efferocytosis.

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来源期刊

Journal of Advanced Research Multidisciplinary-Multidisciplinary

CiteScore

21.60

自引率

0.90%

发文量

280

审稿时长

12 weeks

期刊介绍： Journal of Advanced Research (J. Adv. Res.) is an applied/natural sciences, peer-reviewed journal that focuses on interdisciplinary research. The journal aims to contribute to applied research and knowledge worldwide through the publication of original and high-quality research articles in the fields of Medicine, Pharmaceutical Sciences, Dentistry, Physical Therapy, Veterinary Medicine, and Basic and Biological Sciences. The following abstracting and indexing services cover the Journal of Advanced Research: PubMed/Medline, Essential Science Indicators, Web of Science, Scopus, PubMed Central, PubMed, Science Citation Index Expanded, Directory of Open Access Journals (DOAJ), and INSPEC.