ERK信号可扩展哺乳动物皮质放射状胶质细胞并延长神经源期。

IF 9.4 1区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES
Mengge Sun, Yanjing Gao, Zhenmeiyu Li, Lin Yang, Guoping Liu, Zhejun Xu, Rongliang Guo, Yan You, Zhengang Yang
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引用次数: 0

摘要

皮质在进化过程中扩张的分子基础在很大程度上仍然未知。在这里,我们报告了成纤维细胞生长因子(FGF)-细胞外信号调节激酶(ERK)信号转导促进了皮质放射状胶质细胞(RG)的自我更新和扩张。此外,FGF-ERK 信号还能诱导骨形态发生蛋白 7(Bmp7)在皮质 RG 细胞中的表达,从而延长神经源期。我们证明,ERK 信号和音速刺猬(SHH)信号在皮质 RG 细胞中相互抑制。我们提供的证据表明,ERK 信号在皮质 RG 细胞的发育和进化过程中会升高。我们提出,哺乳动物皮层(尤其是人类)的扩张是由皮层 RG 细胞中的 ERK-BMP7-GLI3R 信号通路驱动的,该通路通过拮抗 SHH 信号参与正反馈循环。我们还提出,小鼠皮层神经源性期相对较短的部分原因是小鼠皮层 RG 细胞接受了较高的 SHH 信号,从而拮抗了 ERK 信号。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
ERK signaling expands mammalian cortical radial glial cells and extends the neurogenic period.

The molecular basis for cortical expansion during evolution remains largely unknown. Here, we report that fibroblast growth factor (FGF)-extracellular signal-regulated kinase (ERK) signaling promotes the self-renewal and expansion of cortical radial glial (RG) cells. Furthermore, FGF-ERK signaling induces bone morphogenic protein 7 (Bmp7) expression in cortical RG cells, which increases the length of the neurogenic period. We demonstrate that ERK signaling and Sonic Hedgehog (SHH) signaling mutually inhibit each other in cortical RG cells. We provide evidence that ERK signaling is elevated in cortical RG cells during development and evolution. We propose that the expansion of the mammalian cortex, notably in human, is driven by the ERK-BMP7-GLI3R signaling pathway in cortical RG cells, which participates in a positive feedback loop through antagonizing SHH signaling. We also propose that the relatively short cortical neurogenic period in mice is partly due to mouse cortical RG cells receiving higher SHH signaling that antagonizes ERK signaling.

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来源期刊
CiteScore
19.00
自引率
0.90%
发文量
3575
审稿时长
2.5 months
期刊介绍: The Proceedings of the National Academy of Sciences (PNAS), a peer-reviewed journal of the National Academy of Sciences (NAS), serves as an authoritative source for high-impact, original research across the biological, physical, and social sciences. With a global scope, the journal welcomes submissions from researchers worldwide, making it an inclusive platform for advancing scientific knowledge.
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