光动力疗法作为洗牙和根面平整术的辅助疗法对牙周炎患者龈下菌斑的临床参数和微生物组成的疗效:分口随机临床试验

IF 4.2 2区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE
Min Nie, Peien Huang, Peiyao Peng, Daonan Shen, Lei Zhao, Duan Jiang, Yuqin Shen, Lai Wei, Paul W. Bible, Jingmei Yang, Jun Wang, Yafei Wu
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引用次数: 0

摘要

研究背景本研究旨在评估光动力疗法(PDT)作为洗牙和根面平整术(SRP)的辅助疗法对牙周炎患者龈下菌斑的临床参数和微生物组成的疗效:17名患者参加了这项分口随机临床试验。将探诊袋深度(PPD)≥5 毫米且不同象限探诊出血的患者随机分为对照组、SRP 后立即使用一次 PDT 组和 SRP 1 周后重复使用三次 PDT 组。在基线、第 2 周和第 8 周收集龈下斑块,进行 16S rRNA 基因测序:结果:17 名患者共 60 个部位完成了为期 8 周的随访,成功对 157 个龈下斑块进行了测序分析。两个主要结果均有显著改善:第 8 周的 PPD 和龈下微生物组成。与对照组相比,重复 PDT 组在第 2 周时 PPD 显著改善,微生物谱发生了重大变化,包括α-多样性和厌氧菌减少,而需氧菌增加。临床附着水平和龈沟出血指数等次要结果在第 8 周也有所改善。此外,与基线相比,单次和多次PDT组的牙周病原体减少,有益菌增加:结论:PDT 可促进牙周炎患者龈下菌斑微生物组成向有利于牙周健康的方向变化,重复 PDT 是一种很有前景的牙周治疗辅助疗法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Efficacy of photodynamic therapy as an adjunct to scaling and root planing on clinical parameters and microbial composition in subgingival plaque of periodontitis patients: A split-mouth randomized clinical trial

Background

The aim of this study was to assess the efficacy of photodynamic therapy (PDT) as an adjunct to scaling and root planing (SRP) on clinical parameters and microbial composition in subgingival plaque of periodontitis patients.

Methods

Seventeen patients were included in this split-mouth randomized clinical trial. Sites with probing pocket depth (PPD) ≥5 mm in combination with bleeding on probing in different quadrants were randomized into the control group, the group with a single PDT application right after SRP, and the group with three repeated PDT applications 1 week after SRP. The subgingival plaque was collected for 16S rRNA gene sequencing at baseline, Week 2, and Week 8.

Results

Seventeen patients with 60 sites completed this 8-week follow-up, and 157 subgingival plaques were successfully analyzed by sequencing. Significant improvements were observed in two primary outcomes: PPD at Week 8 and subgingival microbial composition. Compared to the control group, the repeated-PDT group showed a notable improvement in PPD, substantial alterations in the microbial profile, including a reduction in α-diversity and anaerobic bacteria, and an increase in aerobic bacteria at Week 2. Secondary outcomes, such as clinical attachment level and sulcus bleeding index, also showed improvement at Week 8. Furthermore, both the single- and repeated-PDT groups exhibited a decrease in periodontopathogens and an increase in beneficial bacteria compared with baseline.

Conclusion

PDT promotes changes in the microbial composition of periodontitis patients’ subgingival plaque in a direction favorable to periodontal health, and repeated PDT is a promising adjunctive therapy for periodontal treatment.

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来源期刊
Journal of periodontology
Journal of periodontology 医学-牙科与口腔外科
CiteScore
9.10
自引率
7.00%
发文量
290
审稿时长
3-8 weeks
期刊介绍: The Journal of Periodontology publishes articles relevant to the science and practice of periodontics and related areas.
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