Wen-Jing Hu, Ting-Ting Yang, Ya-Ya Wang, Jiang-Wei Yan
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引用次数: 0
摘要
近年来，随着DNA提取和检测技术的不断进步，无细胞DNA（cell-free DNA，cfDNA）在生命科学领域得到了广泛应用，其在法医鉴定中的潜在应用价值也越来越明显。本文综述了 cfDNA 的概念、形成机理、分类等，并介绍了 cfDNA 在犯罪现场触摸 DNA 样品的个人身份鉴定和无创产前亲子鉴定（NIPPT）中的最新研究进展。同时，本文总结了cfDNA在损伤推断中的潜在应用，探讨了常见cfDNA分析方法和技术的优缺点及其应用前景，为cfDNA在法医学领域的广泛应用提供了新思路。
The Latest Research Progress on Cell-Free DNA and Prospects of Its Forensic Application.
In recent years, with the continuous progress of DNA extraction and detection technology, cell-free DNA(cfDNA)has been widely used in the life science field, and its potential application value in forensic identification is becoming more and more obvious. This paper reviews the concept, formation mechanism, and classification of cfDNA, etc., and describes the latest research progress of cfDNA in personal identification of crime scene touch DNA samples and non-invasive prenatal paternity testing (NIPPT). Meanwhile, this paper summarizes the potential application of cfDNA in injury inference, and discusses the advantages and disadvantages of common cfDNA analysis methods and techniques, and its application prospects, to provide a new idea for the wide application of cfDNA in the field of forensic science.
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