{"title":"分子印迹聚合物作为固相萃取和分散固相萃取吸附剂在水中萃取抗逆转录病毒药物:吸附性、选择性和重复使用性研究","authors":"Thabiso Xolo, Precious Mahlambi","doi":"10.1186/s40543-024-00418-4","DOIUrl":null,"url":null,"abstract":"The antiretroviral drugs (ARVDs) have been reported to be among the emerging water pollutants as a results attention is being paid on their analysis. This work therefore explored for the first time the multi-template MIP for the selective removal of selected ARVDs (abacavir, efavirenz and nevirapine) in wastewater, river water and tap water. The adsorption studies of a multi-template MIP were conducted by determining the effect of an increase in ARVDs concentration in solution and the effect of an increase in contact time between the sorbent and the ARVDs. High adsorption efficiencies were observed for abacavir, efavirenz and nevirapine analytes within 5 min and the maximum adsorption efficiency was observed at 60 min ranging from 94.76 to 96.93%. Adsorption kinetics showed that pseudo-second rate order was the best fitting model, while adsorption isotherms indicated that the Freundlich isotherm (R2 = 0.94–0.98) best described the adsorption mechanism of ARVDs onto the MIPs. These results indicated that the electrostatic attractions influenced the multilayer coverage and chemisorption process. Selectivity studies conducted in the presence of competitors gave the recoveries between 92 and 98% for the target analytes, while they were 63–79% for competitors indicating good selectivity and strong affinity of the polymer towards the target analytes. Reusability studies showed that the MIP can be reused for up to 8 cycles with recoveries above 92% for all target ARVDs. The application of the MIP-DSPE method to wastewater, river and tap water samples gave concentrations of 28.75–178.02, 1.95–13.15 and 2.17–6.27 µg L−1, respectively. These results indicate the potential unplanned consumption of ARVDs upon drinking contaminated water which could result to their resistance by the human body. Therefore, their continuous monitoring as well as investigation of their removal strategies is of paramount importance.","PeriodicalId":14967,"journal":{"name":"Journal of Analytical Science and Technology","volume":"17 1","pages":""},"PeriodicalIF":2.5000,"publicationDate":"2024-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Molecularly imprinted polymers as solid-phase and dispersive solid-phase extraction sorbents in the extraction of antiretroviral drugs in water: adsorption, selectivity and reusability studies\",\"authors\":\"Thabiso Xolo, Precious Mahlambi\",\"doi\":\"10.1186/s40543-024-00418-4\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The antiretroviral drugs (ARVDs) have been reported to be among the emerging water pollutants as a results attention is being paid on their analysis. This work therefore explored for the first time the multi-template MIP for the selective removal of selected ARVDs (abacavir, efavirenz and nevirapine) in wastewater, river water and tap water. The adsorption studies of a multi-template MIP were conducted by determining the effect of an increase in ARVDs concentration in solution and the effect of an increase in contact time between the sorbent and the ARVDs. High adsorption efficiencies were observed for abacavir, efavirenz and nevirapine analytes within 5 min and the maximum adsorption efficiency was observed at 60 min ranging from 94.76 to 96.93%. Adsorption kinetics showed that pseudo-second rate order was the best fitting model, while adsorption isotherms indicated that the Freundlich isotherm (R2 = 0.94–0.98) best described the adsorption mechanism of ARVDs onto the MIPs. These results indicated that the electrostatic attractions influenced the multilayer coverage and chemisorption process. Selectivity studies conducted in the presence of competitors gave the recoveries between 92 and 98% for the target analytes, while they were 63–79% for competitors indicating good selectivity and strong affinity of the polymer towards the target analytes. Reusability studies showed that the MIP can be reused for up to 8 cycles with recoveries above 92% for all target ARVDs. The application of the MIP-DSPE method to wastewater, river and tap water samples gave concentrations of 28.75–178.02, 1.95–13.15 and 2.17–6.27 µg L−1, respectively. These results indicate the potential unplanned consumption of ARVDs upon drinking contaminated water which could result to their resistance by the human body. Therefore, their continuous monitoring as well as investigation of their removal strategies is of paramount importance.\",\"PeriodicalId\":14967,\"journal\":{\"name\":\"Journal of Analytical Science and Technology\",\"volume\":\"17 1\",\"pages\":\"\"},\"PeriodicalIF\":2.5000,\"publicationDate\":\"2024-03-18\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Analytical Science and Technology\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://doi.org/10.1186/s40543-024-00418-4\",\"RegionNum\":4,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, ANALYTICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Analytical Science and Technology","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1186/s40543-024-00418-4","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, ANALYTICAL","Score":null,"Total":0}
Molecularly imprinted polymers as solid-phase and dispersive solid-phase extraction sorbents in the extraction of antiretroviral drugs in water: adsorption, selectivity and reusability studies
The antiretroviral drugs (ARVDs) have been reported to be among the emerging water pollutants as a results attention is being paid on their analysis. This work therefore explored for the first time the multi-template MIP for the selective removal of selected ARVDs (abacavir, efavirenz and nevirapine) in wastewater, river water and tap water. The adsorption studies of a multi-template MIP were conducted by determining the effect of an increase in ARVDs concentration in solution and the effect of an increase in contact time between the sorbent and the ARVDs. High adsorption efficiencies were observed for abacavir, efavirenz and nevirapine analytes within 5 min and the maximum adsorption efficiency was observed at 60 min ranging from 94.76 to 96.93%. Adsorption kinetics showed that pseudo-second rate order was the best fitting model, while adsorption isotherms indicated that the Freundlich isotherm (R2 = 0.94–0.98) best described the adsorption mechanism of ARVDs onto the MIPs. These results indicated that the electrostatic attractions influenced the multilayer coverage and chemisorption process. Selectivity studies conducted in the presence of competitors gave the recoveries between 92 and 98% for the target analytes, while they were 63–79% for competitors indicating good selectivity and strong affinity of the polymer towards the target analytes. Reusability studies showed that the MIP can be reused for up to 8 cycles with recoveries above 92% for all target ARVDs. The application of the MIP-DSPE method to wastewater, river and tap water samples gave concentrations of 28.75–178.02, 1.95–13.15 and 2.17–6.27 µg L−1, respectively. These results indicate the potential unplanned consumption of ARVDs upon drinking contaminated water which could result to their resistance by the human body. Therefore, their continuous monitoring as well as investigation of their removal strategies is of paramount importance.
期刊介绍:
The Journal of Analytical Science and Technology (JAST) is a fully open access peer-reviewed scientific journal published under the brand SpringerOpen. JAST was launched by Korea Basic Science Institute in 2010. JAST publishes original research and review articles on all aspects of analytical principles, techniques, methods, procedures, and equipment. JAST’s vision is to be an internationally influential and widely read analytical science journal. Our mission is to inform and stimulate researchers to make significant professional achievements in science. We aim to provide scientists, researchers, and students worldwide with unlimited access to the latest advances of the analytical sciences.