特约评论--"压力与酒精 "特刊:关于成瘾的直觉(微生物组)感受:与压力和社会系统的相互作用

IF 4.3 2区 医学 Q1 NEUROSCIENCES
Rubén García-Cabrerizo , John F. Cryan
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引用次数: 0

摘要

近年来,人们越来越关注居住在我们肠道中的微生物之间错综复杂、多种多样的联系,以及它们对大脑健康和中枢神经系统疾病的影响。人们已经转变了观念,认识到吸毒上瘾不仅仅是一种影响大脑的疾病,它现在被认为是一种疾病,还涉及肠道微生物群等外部因素,这些因素可能会影响易感性和成瘾行为的发展。此外,与肠道微生物群密切相关的压力和社会互动也是成瘾的强大调节因素。这篇综述深入探讨了微生物群-压力-免疫轴可能影响药物成瘾和社会行为的机制。这项工作综合了临床前和临床证据,证明了压力、社会行为、药物使用障碍和肠道微生物群之间的双向交流,表明肠道微生物可能调节社会压力,对药物成瘾具有重要意义。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A gut (microbiome) feeling about addiction: Interactions with stress and social systems

In recent years, an increasing attention has given to the intricate and diverse connection of microorganisms residing in our gut and their impact on brain health and central nervous system disease. There has been a shift in mindset to understand that drug addiction is not merely a condition that affects the brain, it is now being recognized as a disorder that also involves external factors such as the intestinal microbiota, which could influence vulnerability and the development of addictive behaviors. Furthermore, stress and social interactions, which are closely linked to the intestinal microbiota, are powerful modulators of addiction. This review delves into the mechanisms through which the microbiota-stress-immune axis may shape drug addiction and social behaviors. This work integrates preclinical and clinical evidence that demonstrate the bidirectional communication between stress, social behaviors, substance use disorders and the gut microbiota, suggesting that gut microbes might modulate social stress having a significance in drug addiction.

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来源期刊
Neurobiology of Stress
Neurobiology of Stress Biochemistry, Genetics and Molecular Biology-Biochemistry
CiteScore
9.40
自引率
4.00%
发文量
74
审稿时长
48 days
期刊介绍: Neurobiology of Stress is a multidisciplinary journal for the publication of original research and review articles on basic, translational and clinical research into stress and related disorders. It will focus on the impact of stress on the brain from cellular to behavioral functions and stress-related neuropsychiatric disorders (such as depression, trauma and anxiety). The translation of basic research findings into real-world applications will be a key aim of the journal. Basic, translational and clinical research on the following topics as they relate to stress will be covered: Molecular substrates and cell signaling, Genetics and epigenetics, Stress circuitry, Structural and physiological plasticity, Developmental Aspects, Laboratory models of stress, Neuroinflammation and pathology, Memory and Cognition, Motivational Processes, Fear and Anxiety, Stress-related neuropsychiatric disorders (including depression, PTSD, substance abuse), Neuropsychopharmacology.
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