短期暴露于香烟烟雾会上调 cathepsin S 并改变紧密连接 ZO-1 的表达。

IF 3.3 3区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
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引用次数: 0

摘要

长期暴露于香烟烟雾(CS)会改变气道上皮屏障的完整性,导致肺功能障碍,并引起肺猫蛋白酶 S(CatS)的表达和活性,猫蛋白酶是一种参与结缔组织和细胞连接重塑的半胱氨酸蛋白酶。在这里,我们观察到小鼠短期(4 天)暴露于 CS 会增加 CatS 的表达和活性,而肺组织裂解液中上皮紧密连接蛋白 Zonula occludens 1(ZO-1)的表达水平会降低,ZO-1 可稳定屏障的组装。目前的数据支持蛋白水解活性 CatS 可能是导致暴露于 CS 的小鼠 ZO-1 缺陷的原因。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Short-term exposure to cigarette smoke upregulates cathepsin S and alters expression of tight junction ZO-1
A long-term exposure to cigarette smoke (CS) alters the integrity of airway epithelial barrier, contributes to lung dysfunction, and elicits the expression and activity of lung cathepsin S (CatS), a cysteine protease that participates in the remodeling of connective tissue and cell junctions. Here, we observed that a short-term (4 days) exposure of mice to CS increased the expression and activity of CatS, while the expression level of zonula occludens 1 (ZO-1), an epithelial tight junction protein that stabilizes barrier assembly, was reduced in lung tissue lysates. Present data support that proteolytically active CatS may contribute to the defect of ZO-1 in CS-exposed mice.
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来源期刊
Biochimie
Biochimie 生物-生化与分子生物学
CiteScore
7.20
自引率
2.60%
发文量
219
审稿时长
40 days
期刊介绍: Biochimie publishes original research articles, short communications, review articles, graphical reviews, mini-reviews, and hypotheses in the broad areas of biology, including biochemistry, enzymology, molecular and cell biology, metabolic regulation, genetics, immunology, microbiology, structural biology, genomics, proteomics, and molecular mechanisms of disease. Biochimie publishes exclusively in English. Articles are subject to peer review, and must satisfy the requirements of originality, high scientific integrity and general interest to a broad range of readers. Submissions that are judged to be of sound scientific and technical quality but do not fully satisfy the requirements for publication in Biochimie may benefit from a transfer service to a more suitable journal within the same subject area.
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