FIRRM和FIGNL1：同源重组调控中的伙伴。

IF 13.6 2区生物学 Q1 GENETICS & HEREDITY

Trends in Genetics Pub Date : 2024-06-01 Epub Date: 2024-03-16 DOI:10.1016/j.tig.2024.02.007

Stavroula Tsaridou, Marcel A T M van Vugt

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引用次数: 0

摘要

通过同源重组（HR）进行DNA修复对维持基因组稳定性和防止肿瘤发生至关重要。RAD51 是 HR 的核心成分，催化链侵入和同源搜索。在此，我们重点介绍最近关于 FIRRM 和 FIGNL1 作为 RAD51 动态调控因子的研究结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

FIRRM and FIGNL1: partners in the regulation of homologous recombination.

DNA repair through homologous recombination (HR) is of vital importance for maintaining genome stability and preventing tumorigenesis. RAD51 is the core component of HR, catalyzing the strand invasion and homology search. Here, we highlight recent findings on FIRRM and FIGNL1 as regulators of the dynamics of RAD51.

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来源期刊

Trends in Genetics 生物-遗传学

CiteScore

20.90

自引率

0.90%

发文量

160

审稿时长

6-12 weeks

期刊介绍： Launched in 1985, Trends in Genetics swiftly established itself as a "must-read" for geneticists, offering concise, accessible articles covering a spectrum of topics from developmental biology to evolution. This reputation endures, making TiG a cherished resource in the genetic research community. While evolving with the field, the journal now embraces new areas like genomics, epigenetics, and computational genetics, alongside its continued coverage of traditional subjects such as transcriptional regulation, population genetics, and chromosome biology. Despite expanding its scope, the core objective of TiG remains steadfast: to furnish researchers and students with high-quality, innovative reviews, commentaries, and discussions, fostering an appreciation for advances in genetic research. Each issue of TiG presents lively and up-to-date Reviews and Opinions, alongside shorter articles like Science & Society and Spotlight pieces. Invited from leading researchers, Reviews objectively chronicle recent developments, Opinions provide a forum for debate and hypothesis, and shorter articles explore the intersection of genetics with science and policy, as well as emerging ideas in the field. All articles undergo rigorous peer-review.