认知测试分数与疼痛耐受力之间的关系:特罗姆瑟研究

IF 1.5 Q4 CLINICAL NEUROLOGY
Scandinavian Journal of Pain Pub Date : 2024-03-18 eCollection Date: 2024-01-01 DOI:10.1515/sjpain-2023-0082
Tonje Anita Melum, Ólöf A Steingrímsdóttir, Henrik B Jacobsen, Bente Johnsen, Audun Stubhaug, Henrik Schirmer, Ellisiv B Mathiesen, Christopher S Nielsen
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引用次数: 0

摘要

研究目的以往的研究表明,实验性疼痛敏感性与认知功能有关。本研究的目的是在一个大样本人群中评估这种关系:我们纳入了特罗姆瑟人口研究第七次调查中的 5753 名参与者(年龄在 40-84 岁之间),他们都接受过认知测试和实验性疼痛评估,并提供了协变量信息。以认知测试(12 个单词即时回忆测试、数字符号编码测试和迷你精神状态检查 [MMS-E])的标准化分数为自变量,以冷压器或袖套压力疼痛耐受性为因变量,拟合了 Cox 回归模型。对假定的混杂因素,即年龄、性别、教育程度、吸烟、运动、收缩压、体重指数、焦虑或抑郁症状、镇痛剂的使用和慢性疼痛,进行了统计调整:在多变量分析中,冷压耐受时间与 12 个单词即时回忆测试得分(危险比 [HR] 0.93,95% 置信区间 [CI] 0.90-0.97,p < 0.001)、数字符号编码测试(HR 0.94,95% CI 0.89-0.98,p = 0.004)和 MMS-E 测试(HR 0.93,95% CI 0.90-0.96 p < 0.001)显著相关。对袖带压力算法的耐受性与12个单词的即时回忆(HR 0.94-0.97,p < 0.001)和数字符号编码测试得分(HR 0.93,95% CI 0.89-0.96,p < 0.001)显著相关,而与迷你精神状态检查测试得分(HR 0.98,95% CI 0.95-1.00,p = 0.082)无显著相关:结论:疼痛耐受力较低与认知测试成绩较差有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Associations between cognitive test scores and pain tolerance: The Tromsø study.

Objectives: Previous studies have suggested that experimental pain sensitivity is associated with cognitive function. The aim of this study is to assess this relationship in a large population-based sample.

Methods: We included 5,753 participants (aged 40-84 years) from the seventh wave of the population-based Tromsø Study who had been examined with cognitive tests and experimental pain assessments, and for whom information on covariates were available. Cox regression models were fitted using standardized scores on cognitive tests (12-word immediate recall test, digit symbol coding test, and Mini-Mental State Examination [MMS-E]) as the independent variable and cold pressor or cuff pressure pain tolerance as the dependent variables. Statistical adjustment was made for putative confounders, namely, age, sex, education, smoking, exercise, systolic blood pressure, body mass index, symptoms indicating anxiety or depression, analgesic use, and chronic pain.

Results: In multivariate analysis, cold pressor tolerance time was significantly associated with test scores on the 12-word immediate recall test (hazard ratio [HR] 0.93, 95% confidence interval [CI] 0.90-0.97, p < 0.001), the digit symbol coding test (HR 0.94, 95% CI 0.89-0.98, p = 0.004), and the MMS-E (HR 0.93, 95% CI 0.90-0.96 p < 0.001). Tolerance to cuff pressure algometry was significantly associated with 12-word immediate recall (HR 0.94-0.97, p < 0.001) and Digit Symbol Coding test scores (HR 0.93, 95% CI 0.89-0.96, p < 0.001) while there was no significant association with Mini Mental State Examination test score (HR 0.98, 95% CI 0.95-1.00, p = 0.082).

Conclusion: Lower pain tolerance was associated with poorer performance on cognitive tests.

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来源期刊
Scandinavian Journal of Pain
Scandinavian Journal of Pain CLINICAL NEUROLOGY-
CiteScore
3.30
自引率
6.20%
发文量
73
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