中药纳米药物的联合药物疗法可防止多药耐药蛋白 1:促进肺癌细胞凋亡。

IF 3.1 4区 医学 Q2 BIOPHYSICS
Ashraf Alemi, Mojtaba Haghi Karamallah, Mohamad Sabaghan, Seyed Ahmad Hosseini, Ali Veisi, Somayeh Haghi Karamallah, Mohammad Farokhifar
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引用次数: 0

摘要

鉴于肺癌治疗的诸多不良反应,迫切需要对无毒药物进行更多研究。姜黄素(CUR)和小檗碱(BBR)通过控制多药耐药泵(MDR1)的表达来对抗耐药性。令人称奇的是,将这两种药物结合使用可提高预防肺癌的效果。然而,这些药物溶解度低、稳定性差,限制了它们的疗效。由于水不溶性药物的生物利用度提高,封装效果增强,基于表面活性剂的纳米颗粒最近受到了广泛关注。本研究试图阐明中药纳米药物的联合用药治疗可防止多药耐药蛋白 1:促进肺癌细胞凋亡。研究评估了几种具有不同疏水性尾部的吐温(20、60 和 80)对 BBR/CUR-TNV 的影响。此外,还评估了 BBR/CUR-TNV 联合疗法的 MDR1 活性和凋亡率。TNV的封装效果受吐温类型的影响。用吐温 60、胆固醇和 PEG(47.5: 47.5:5)制成的 TNV 可达到更高的封装效果。将 CUR 与 BBR 结合使用,尤其是在 TNV 中使用时,细胞凋亡率会增加。此外,当 CUR 和 BBR 联合给药时,它们能显著降低 MDR1 发生的风险。目前的研究结果表明,通过基于吐温的纳米颗粒将小檗碱和姜黄素作为联合用药治疗可能是一种潜在的肺癌治疗方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Combination drug therapy by herbal nanomedicine prevent multidrug resistance protein 1: promote apoptosis in Lung Carcinoma.

Given the numerous adverse effects of lung cancer treatment, more research on non-toxic medications is urgently needed. Curcumin (CUR) and berberine (BBR) combat drug resistance by controlling the expression of multidrug resistant pump (MDR1). Fascinatingly, combining these medications increases the effectiveness of preventing lung cancer. Their low solubility and poor stability, however, restrict their therapeutic efficacy. Because of the improved bioavailability and increased encapsulation effectiveness of water-insoluble medicines, surfactant-based nanovesicles have recently received a great deal of attention. The current study sought to elucidate the Combination drug therapy by herbal nanomedicine prevent multidrug resistance protein 1: promote apoptosis in Lung Carcinoma. The impact of several tween (20, 60, and 80) types with varied hydrophobic tails on BBR/CUR-TNV was evaluated. Additionally, the MDR1 activity and apoptosis rate of the BBR/CUR-TNV combination therapy were assessed. The encapsulation effectiveness of TNV was affected by the type of tween. With the TNV made from tween 60, cholesterol, and PEG (47.5: 47.5:5), more encapsulation effectiveness was attained. By combining CUR with BBR, especially when given in TNV, apoptosis increased. Additionally, when CUR and BBR were administered in combination, they significantly reduced the risk of MDR1 development. The current work suggests that the delivery of berberine and curcumin as a combination medication therapy via tween-based nanovesicles may be a potential lung cancer treatment.

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来源期刊
Journal of Applied Biomaterials & Functional Materials
Journal of Applied Biomaterials & Functional Materials BIOPHYSICS-ENGINEERING, BIOMEDICAL
CiteScore
4.40
自引率
4.00%
发文量
36
审稿时长
>12 weeks
期刊介绍: The Journal of Applied Biomaterials & Functional Materials (JABFM) is an open access, peer-reviewed, international journal considering the publication of original contributions, reviews and editorials dealing with clinical and laboratory investigations in the fast growing field of biomaterial sciences and functional materials. The areas covered by the journal will include: • Biomaterials / Materials for biomedical applications • Functional materials • Hybrid and composite materials • Soft materials • Hydrogels • Nanomaterials • Gene delivery • Nonodevices • Metamaterials • Active coatings • Surface functionalization • Tissue engineering • Cell delivery/cell encapsulation systems • 3D printing materials • Material characterization • Biomechanics
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