姜黄中基于肠肝轴心的抗肝胆疾病成分:药理特性和潜在临床应用。

The American journal of Chinese medicine Pub Date : 2024-01-01 Epub Date: 2024-03-16 DOI:10.1142/S0192415X24500162
Tianhui Gao, Shuyi Wang, Zongping Zhu, Liting Lin, Yirong Luo, Meigui Lu, Wan Liao
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引用次数: 0

摘要

姜黄在世界范围内被广泛使用,在治疗肝胆疾病方面也有许多实例。肠肝轴是肠道微生物与肝脏之间的双向关系,与肝胆疾病的发病机制密切相关。本综述系统地总结了姜黄的成分。它将姜黄影响肠道微生物的研究与其对肝胆疾病的影响联系起来,解释了姜黄调节肠肝轴的潜在机制。此外,还对姜黄的民族药理学、植物化学成分和临床不良反应进行了研究。此外,姜黄是一种安全的药物,具有良好的临床疗效,且在一定量下无明显毒性。通过总结姜黄通过调节肠肝轴,尤其是肠道微生物群对肝脏的影响,为基于肠肝轴将姜黄作为一种安全有效的治疗药物用于预防和治疗肝胆疾病提供了临床前基础。然而,要进一步开发其临床应用,还需付出更多努力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Components from Curcuma longa (Turmeric) Against Hepatobiliary Diseases Based on Gut-Liver Axis: Pharmacotherapeutic Properties and Potential Clinical Applications.

Turmeric is widely used worldwide, and there are many examples of its use in treating hepatobiliary diseases. The gut-liver axis is a bidirectional relationship between gut microorganisms and the liver that is closely related to the pathogenesis of hepatobiliary diseases. This review systematically summarizes the components of turmeric. It links the studies on turmeric affecting gut microorganisms to its effects on liver and biliary diseases to explain the potential mechanism of turmeric's regulation of the gut-liver axis. Besides, ethnopharmacology, phytochemicals, and clinical adverse events associated with turmeric have been researched. Furthermore, turmeric is a safe agent with good clinical efficacy and without apparent toxicity at a certain amount. By summarizing the influence of turmeric on the liver by regulating the gut-liver axis, especially the gut microbiota, it provides a preclinical basis for using turmeric as a safe and effective therapeutic agent for the prevention and treatment of hepatobiliary diseases based on the gut-liver axis. However, more efforts should be made to exploit its clinical application further.

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