神经内分泌肿瘤的肽受体放射性核素疗法:激动剂、拮抗剂和替代品。

IF 4.6 2区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
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引用次数: 0

摘要

如今,肽受体放射性核素疗法(PRRT)已成为治疗神经内分泌肿瘤(NET)患者的一种行之有效的治疗策略。肽受体放射性核素疗法早在 30 多年前就已开始应用,但直到近几年才被纳入主要的肿瘤学指南,其依据是在临床试验中被证实的有效性和安全性。继 3 期 NETTER-1 试验促使放射性药物 Luthatera® 于 2017 年最终注册用于治疗 G1/G2 NET 患者之后,3 期 NETTER-2 试验的长期结果可能会为晚期 G2/G3 患者的一线治疗铺平道路。随着人们对联合疗法协同作用的认识不断加深,也可以为NET患者提供其他(再)治疗方案,以制定量身定制的治疗策略。不断发展的治疗概念可用于识别可能受益于不同图像引导治疗策略的患者。在这种情况下,目前正在讨论对NET患者使用双示踪剂PET/CT,同时使用[18F]F-FDG/[68Ga]Ga-DOTA-somatostatin analog (SSA)进行诊断和随访,这也可能成为一种强大的预后工具。此外,还可以采用基于不同代谢途径、放射性同位素或不同医疗方法组合的替代策略。因此,在不久的将来,治疗母细胞瘤患者的许多不同的 "大门 "都将打开,而 "钥匙 "将是治疗学!
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Peptide Receptor Radionuclide Therapy of Neuroendocrine Tumors: Agonist, Antagonist and Alternatives

Peptide receptor radionuclide therapy (PRRT) today is a well-established treatment strategy for patients with neuroendocrine tumors (NET). First performed already more than 30 years ago, PRRT was incorporated only in recent years into the major oncology guidelines, based on its proven efficacy and safety in clinical trials. Following the phase 3 NETTER-1 trial, which led to the final registration of the radiopharmaceutical Luthatera® for G1/G2 NET patients in 2017, the long-term results of the phase 3 NETTER-2 trial may pave the way for a new treatment option also for advanced G2/G3 patients as first-line therapy. The growing knowledge about the synergistic effect of combined therapies could also allow alternative (re)treatment options for NET patients, in order to create a tailored treatment strategy. The evolving thera(g)nostic concept could be applied for the identification of patients who might benefit from different image-guided treatment strategies. In this scenario, the use of dual tracer PET/CT in NET patients, using both [18F]F-FDG/[68Ga]Ga-DOTA-somatostatin analog (SSA) for diagnosis and follow-up, is under discussion and could also result in a powerful prognostic tool. In addition, alternative strategies based on different metabolic pathways, radioisotopes, or combinations of different medical approaches could be applied. A number of different promising “doors” could thus open in the near future for the treatment of NET patients - and the “key” will be thera(g)nostic!

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来源期刊
Seminars in nuclear medicine
Seminars in nuclear medicine 医学-核医学
CiteScore
9.80
自引率
6.10%
发文量
86
审稿时长
14 days
期刊介绍: Seminars in Nuclear Medicine is the leading review journal in nuclear medicine. Each issue brings you expert reviews and commentary on a single topic as selected by the Editors. The journal contains extensive coverage of the field of nuclear medicine, including PET, SPECT, and other molecular imaging studies, and related imaging studies. Full-color illustrations are used throughout to highlight important findings. Seminars is included in PubMed/Medline, Thomson/ISI, and other major scientific indexes.
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