pH 敏感型和非 pH 敏感型紫杉醇递送纳米粒子在癌症治疗中的药效比较

IF 4.4 4区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Macromolecular bioscience Pub Date : 2024-03-15 DOI:10.1002/mabi.202400009

Jianquan Wang, Xinyan Ruan, Hangmin Guan, Hailuo Fu, Shichao Ai, Yiqing Wang

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引用次数: 0

摘要

紫杉醇是最广泛使用的化疗药物之一，但在临床实践中却因其溶解性差和严重的副作用而受到限制。为了克服这些限制，研究人员开发了对 pH 值敏感的纳米颗粒--乙缩醛右旋糖酐 6k -PEG5k -PLA2k -紫杉醇（ADPP-PTX）和对 pH 值不敏感的纳米颗粒--丙酸酐修饰右旋糖酐 6k -PEG5k -PLA2k -紫杉醇（PDPP-PTX），用于递送紫杉醇。与 PDPP-PTX 相比，ADPP-PTX 对酸反应的敏感性更高，对癌细胞的抗增殖作用也更强。在体内研究中，ADPP-PTX治疗能有效抑制肿瘤生长，而使用的紫杉醇剂量仅为紫杉醇的一半，与紫杉醇和PDPP-PTX相比，显著降低了全身毒性。本文受版权保护。保留所有权利。

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Drug Efficacy Comparison of pH-Sensitive and Non-pH-Sensitive Taxol Delivery Nanoparticles in Cancer Therapy

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Drug Efficacy Comparison of pH-Sensitive and Non-pH-Sensitive Taxol Delivery Nanoparticles in Cancer Therapy

Taxol is one of the most widely used chemotherapeutic agents but is restricted by its poor solubility and severe side effects in clinical practice. To overcome these limitations, pH-sensitive nanoparticles, Acetalated Dextran_6k-PEG_5k-PLA_2k-Taxol (ADPP-PTX), non-pH-sensitive nanoparticles, and Propionic Anhydride modified Dextran_6k-PEG_5k-PLA_2k-Taxol (PDPP-PTX) are developed for the delivery of Taxol. Compared with PDPP-PTX, ADPP-PTX shows higher sensitivity to acid response and greater anti-proliferative effect on cancer cells. In the in vivo study, ADPP-PTX treatment effectively suppresses the growth of tumors, while only half the dose of Taxol is used, which significantly reduces systemic toxicity compared with Taxol and PDPP-PTX.

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来源期刊

Macromolecular bioscience 生物-材料科学：生物材料

CiteScore

7.90

自引率

2.20%

发文量

211

审稿时长

1.5 months

期刊介绍： Macromolecular Bioscience is a leading journal at the intersection of polymer and materials sciences with life science and medicine. With an Impact Factor of 2.895 (2018 Journal Impact Factor, Journal Citation Reports (Clarivate Analytics, 2019)), it is currently ranked among the top biomaterials and polymer journals. Macromolecular Bioscience offers an attractive mixture of high-quality Reviews, Feature Articles, Communications, and Full Papers. With average reviewing times below 30 days, publication times of 2.5 months and listing in all major indices, including Medline, Macromolecular Bioscience is the journal of choice for your best contributions at the intersection of polymer and life sciences.