血管紧张素 II 在非酒精性脂肪变性中的作用

IF 4.7 3区 医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL
Zimri Aziel Alvarado-Ojeda , Celeste Trejo-Moreno , Eduardo Ferat-Osorio , Marisol Méndez-Martínez , Gladis Fragoso , Gabriela Rosas-Salgado
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引用次数: 0

摘要

脂肪肝是一种多因素疾病,其特点是肝细胞中脂类过度积累(脂肪变性)、胰岛素抵抗、氧化应激和炎症。这种疾病对公众健康有重大影响,因为它是肝脏慢性退化过程的第一阶段,可导致脂肪性肝炎、肝硬化和肝癌。虽然这种疾病主要在肥胖、2 型糖尿病和血脂异常的患者中确诊,但最近的证据表明,血管紧张素 II(ANGII)等血管活性激素不仅会促进内皮功能障碍(ED)和高血压,还会导致脂肪肝、增加脂肪组织,并形成以低水平全身促炎症和促氧化状态为特征的促静态环境,同时导致血脂水平升高。有关 ANGII 在脂质蓄积中的作用的研究很少,因此本综述旨在总结有关 ANGII 诱导肝细胞脂质蓄积的可能作用机制的现有报道。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Role of Angiotensin II in Non-Alcoholic Steatosis Development

Fatty liver is a multifactorial disease characterized by excessive accumulation of lipids in hepatocytes (steatosis), insulin resistance, oxidative stress, and inflammation. This disease has a major public health impact because it is the first stage of a chronic and degenerative process in the liver that can lead to steatohepatitis, cirrhosis, and liver cancer. Although this disease is mainly diagnosed in patients with obesity, type 2 diabetes mellitus, and dyslipidemia, recent evidence indicates that vasoactive hormones such as angiotensin II (ANGII) not only promote endothelial dysfunction (ED) and hypertension, but also cause fatty liver, increase adipose tissue, and develop a pro-steatotic environment characterized by a low-grade systemic pro-inflammatory and pro-oxidant state, with elevated blood lipid levels. The role of ANGII in lipid accumulation has been little studied, so this review aims to summarize existing reports on the possible mechanism of action of ANGII in inducing lipid accumulation in hepatocytes.

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来源期刊
Archives of Medical Research
Archives of Medical Research 医学-医学:研究与实验
CiteScore
12.50
自引率
0.00%
发文量
84
审稿时长
28 days
期刊介绍: Archives of Medical Research serves as a platform for publishing original peer-reviewed medical research, aiming to bridge gaps created by medical specialization. The journal covers three main categories - biomedical, clinical, and epidemiological contributions, along with review articles and preliminary communications. With an international scope, it presents the study of diseases from diverse perspectives, offering the medical community original investigations ranging from molecular biology to clinical epidemiology in a single publication.
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