评估氟西汀治疗后窝手术后儿童小脑缄默综合征的安全性。

IF 1.3 4区 医学 Q3 PEDIATRICS
Roxane Varengue , Matthieu Delion , Emilie De Carli , Luc Le Fournier , Julien Durigneux , Mickael Dinomais , Patrick Van Bogaert
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引用次数: 0

摘要

背景:在接受后窝肿瘤手术的儿童中,8%-29%会出现小脑缄默综合征(CMS)。其主要症状是缄默和情绪不稳。虽然小脑缄默综合征总是一过性的,但恢复时间可能较长,并伴有长期认知后遗症。目前还没有获得批准的治疗 CMS 的药物,但在日常医疗实践中使用了一些药物。氟西汀就是其中之一,在我院已使用多年。本研究的主要目的是确定氟西汀在这种情况下的安全性:对昂热大学医院 2010 年至 2020 年期间脑外科手术后入住儿科重症监护室的患者病历进行回顾。研究对象包括接受后窝肿瘤手术并被诊断为CMS的2岁及以上儿童。研究人员收集了患者特征、氟西汀治疗处方、副作用(如有)和完全缄默持续时间等数据:结果:在研究期间,儿科重症监护室共收治了246名接受脑部手术的患者,其中23人患有CMS,8人接受了氟西汀治疗。没有与氟西汀相关的严重不良事件报告。氟西汀组与非氟西汀组的完全缄默期没有明显差异(P = 0.22)。然而,半数接受治疗的患者在完全缄默症恢复后才开始接受治疗:这项研究表明,氟西汀用于术后 CMS 具有积极的安全性。结论:这项研究表明,氟西汀用于术后 CMS 具有良好的安全性,但并未回答这种治疗方法是否有效的问题。应根据综合征严重程度量表进行随机对照试验,以便对氟西汀的疗效和安全性进行更可靠的评估。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Evaluation of safety of fluoxetine for cerebellar mutism syndrome in children after posterior fossa surgery

Background

Cerebellar mutism syndrome (CMS) occurs in 8–29 % of children undergoing posterior fossa tumor surgery. Its main symptoms are mutism and emotional lability. Although it is always transient, recovery time can be lengthy with long-term cognitive sequelae. There is no approved drug treatment for CMS, but some drugs are used in everyday medical practice. One of these is fluoxetine, which has been used for many years in our institution. The main objective of this study was to establish the safety profile of fluoxetine in this condition.

Materials and methods

The records of patients admitted to the pediatric intensive care unit after brain surgery at Angers University Hospital from 2010 to 2020 were reviewed. Children aged 2 years and older who underwent a posterior fossa tumor surgery and were diagnosed with CMS were included. Data on patient characteristics, prescription of fluoxetine treatment, side effects if any, and complete mutism duration were collected.

Results

Among 246 patients admitted to the pediatric intensive care unit for brain surgery during the study period, 23 had CMS and eight were prescribed fluoxetine. No serious adverse event related to fluoxetine was reported. Complete mutism duration did not differ significantly between the fluoxetine group and the non-fluoxetine group(p = 0.22). However, the treatment was initiated after recovery from complete mutism in half of the treated patients.

Conclusion

This study suggests a positive safety profile of fluoxetine used in postoperative CMS. It does not answer the question of whether the treatment is effective for this indication. A randomized controlled trial based on a syndrome severity scale should be conducted to provide a more reliable assessment of the efficacy and safety of fluoxetine.

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来源期刊
Archives De Pediatrie
Archives De Pediatrie 医学-小儿科
CiteScore
2.80
自引率
5.60%
发文量
106
审稿时长
24.1 weeks
期刊介绍: Archives de Pédiatrie publishes in English original Research papers, Review articles, Short communications, Practice guidelines, Editorials and Letters in all fields relevant to pediatrics. Eight issues of Archives de Pédiatrie are released annually, as well as supplementary and special editions to complete these regular issues. All manuscripts submitted to the journal are subjected to peer review by international experts, and must: Be written in excellent English, clear and easy to understand, precise and concise; Bring new, interesting, valid information - and improve clinical care or guide future research; Be solely the work of the author(s) stated; Not have been previously published elsewhere and not be under consideration by another journal; Be in accordance with the journal''s Guide for Authors'' instructions: manuscripts that fail to comply with these rules may be returned to the authors without being reviewed. Under no circumstances does the journal guarantee publication before the editorial board makes its final decision. Archives de Pédiatrie is the official publication of the French Society of Pediatrics.
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