高血压或糖尿病高危肥胖孕妇口服和阴道给药米索前列醇引产的有效性和安全性。

IF 1.7 4区 医学 Q3 OBSTETRICS & GYNECOLOGY
Shi Tian, Li Wang, Yi-Wei Han, Yan-Nan Liu, Feng-Qiu Li, Xiao-Hua Jin
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引用次数: 0

摘要

研究目的本研究旨在比较米索前列醇口服和阴道给药对患有妊娠高血压或糖尿病的肥胖临产孕妇的安全性和有效性:共有264名孕妇被纳入研究,并根据其主要病症分为两组:高血压(134例)或糖尿病(130例),并进一步将其分为口服(口服组)或阴道(阴道组)米索前列醇给药亚组。测量的主要结果包括治疗后 Bishop 评分的变化、引产(IOL)成功率、催产素扩容需求、产程、分娩方式和剖宫产率:结果:两组产妇的 Bishop 评分均显著提高,剖宫产率降低,IOL 成功率提高。与口服组相比,阴道组在 24 小时内经阴道分娩的发生率明显更高。阴道组的不良反应包括恶心、子宫过度收缩、子宫收缩频率过快和子宫过度刺激,但无胎儿心率减慢,其发生率明显高于口服组:结论:米索前列醇口服和阴道给药对患有高血压或糖尿病的肥胖孕妇引产有效。结论:米索前列醇口服和阴道给药对患有高血压或糖尿病的肥胖孕妇引产均有效,但口服给药的孕产妇和新生儿不良结局风险较低,这表明口服给药更适用于此类人群,引产更安全。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Efficacy and safety of oral and vaginal administration of misoprostol for induction of labor in high-risk obese pregnant women with hypertension or diabetes mellitus.

Objective: This study aims to compare the safety and efficacy of misoprostol administered orally and vaginally in obese pregnant women at term with either gestational hypertension or diabetes.

Methods: A total of 264 pregnant women were enrolled and categorized into two groups based on their primary condition: hypertension (134 cases) or diabetes mellitus (130 cases) and were further divided into subgroups for misoprostol administration: orally (Oral group) or vaginally (Vaginal group). The primary outcomes measured were changes in the Bishop score following treatment, induction of labor (IOL) success rates, requirement for oxytocin augmentation, duration of labor, mode of delivery, and cesarean section rates.

Results: Significant enhancements in Bishop scores, decreased cesarean section rates and increased success rates of IOL were noted in both administration groups. The incidence of vaginal delivery within 24 h was significantly higher in the Vaginal group compared to the Oral group. Adverse effects, including nausea, uterine overcontraction, hyperfrequency of uterine contraction and uterine hyperstimulation without fetal heart rate deceleration, were significantly more prevalent in the Vaginal group than in the Oral group.

Conclusion: Misoprostol administration, both orally and vaginally, proves effective for labor induction in obese pregnant women with hypertension or diabetes. However, the oral route presents a lower risk of adverse maternal and neonatal outcomes, suggesting its preference for safer labor induction in this demographic.

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来源期刊
CiteScore
4.40
自引率
0.00%
发文量
217
审稿时长
2-3 weeks
期刊介绍: The official journal of The European Association of Perinatal Medicine, The Federation of Asia and Oceania Perinatal Societies and The International Society of Perinatal Obstetricians. The journal publishes a wide range of peer-reviewed research on the obstetric, medical, genetic, mental health and surgical complications of pregnancy and their effects on the mother, fetus and neonate. Research on audit, evaluation and clinical care in maternal-fetal and perinatal medicine is also featured.
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