Xijuan Wang, Ying Meng, Dan Song, Cunxin Tan, Guanzheng Wang, Bin Lv, Yuan Ni, Guotong Xie, Ting Cui, Yan Zhang, Yaqian Niu, Chengxia Zhang, Guangfeng Liu
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Skeleton density (SD) value, vessel density (VD) value, fractal dimension (FD) value, vessel diameter index (VDI) value, foveal avascular zone (FAZ) value are analyzed.</p><p><strong>Results: </strong>A total of 39 participants are included in this study. The SD value in the experimental group was significantly lower than that in control group (0.175 [0.166, 0.181] vs. 0.184 [0.175, 0.188], p = 0.017). Similarly, the VD value in the experimental group was significantly lower than that in the control group (0.333 [0.320, 0.350] vs. 0.354 [0.337, 0.364], p = 0.024). Additionally, the FD value in the experimental group was significantly lower than that in the control group (2.088 [2.083, 2.094] vs. 2.096 [2.090, 2.101], p = 0.022). 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引用次数: 0
摘要
研究目的本研究旨在通过光学相干断层血管造影术比较莫亚莫亚病患者视网膜血管参数和密度：本临床试验共纳入 39 名参与者的 78 只眼睛，将所有这些 Moyamoya 病患者（N=13）设为实验组，将年龄和性别匹配的健康参与者设为对照组（N=26）。然后，所有参与者都接受光学相干断层扫描血管成像检测。收集并分析参与者的一般数据。分析骨架密度（SD）值、血管密度（VD）值、分形维度（FD）值、血管直径指数（VDI）值、眼窝血管区（FAZ）值：本研究共纳入 39 名参与者。实验组的 SD 值明显低于对照组 [0.175 (0.166, 0.181) vs. 0.184 (0.175, 0.188)，P=0.017]。同样，实验组的 VD 值也明显低于对照组 [0.333 (0.320, 0.350) vs. 0.354 (0.337, 0.364)，P=0.024]。此外，实验组的 FD 值明显低于对照组 [2.088 (2.083, 2.094) vs. 2.096 (2.090, 2.101)，P=0.022]。至于 VDI 和 FAZ，实验组的 VDI 值和 FAZ 值均低于对照组，两组间的 VDI 值和 FAZ 值无显著差异：我们的研究采用无创、快速的 OCTA 成像技术，证实了莫亚莫亚病患者视网膜血管参数和密度的降低。
Comparison of Changes in Retinal Vascular Parameters and Density in Patients with Moyamoya Disease: A Retrospective Study.
Introduction: This study aimed to compare retinal vascular parameters and density in patients with moyamoya disease using the optical coherence tomography angiography.
Methods: This clinical trial totally enrolls 78 eyes from 39 participants, and all these patients with moyamoya disease (N = 13) are set as experimental group and participants with health who matched with age and gender are considered as the control group (N = 26). Then all these participants receive optical coherence tomography angiography detection. Participants' general data are collected and analyzed. Skeleton density (SD) value, vessel density (VD) value, fractal dimension (FD) value, vessel diameter index (VDI) value, foveal avascular zone (FAZ) value are analyzed.
Results: A total of 39 participants are included in this study. The SD value in the experimental group was significantly lower than that in control group (0.175 [0.166, 0.181] vs. 0.184 [0.175, 0.188], p = 0.017). Similarly, the VD value in the experimental group was significantly lower than that in the control group (0.333 [0.320, 0.350] vs. 0.354 [0.337, 0.364], p = 0.024). Additionally, the FD value in the experimental group was significantly lower than that in the control group (2.088 [2.083, 2.094] vs. 2.096 [2.090, 2.101], p = 0.022). As for the VDI and FAZ, VDI and FAZ values in the experimental group were lower than those in the control group, there was no significant difference in VDI and FAZ values between the two groups.
Conclusions: Our study, using non-invasive and rapid OCTA imaging, confirmed decreased retinal vascular parameters and density in patients with moyamoya disease.
期刊介绍：
''Ophthalmic Research'' features original papers and reviews reporting on translational and clinical studies. Authors from throughout the world cover research topics on every field in connection with physical, physiologic, pharmacological, biochemical and molecular biological aspects of ophthalmology. This journal also aims to provide a record of international clinical research for both researchers and clinicians in ophthalmology. Finally, the transfer of information from fundamental research to clinical research and clinical practice is particularly welcome.
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