姜黄素对糖尿病血液透析患者颈动脉内膜厚度和脉搏波速度的影响:一项随机、双盲、安慰剂对照试验

IF 1.7 Q2 MEDICINE, GENERAL & INTERNAL
International Journal of Preventive Medicine Pub Date : 2024-01-31 eCollection Date: 2024-01-01 DOI:10.4103/ijpvm.ijpvm_55_22
Mojtaba Ghasemiadl, Soheil Ghasemi, Alireza Soleimani, Mahsa M Esfahani, Javid Azadbakht, Hamid R Gilasi, Hamid R Talari
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引用次数: 0

摘要

背景:先前的研究表明,姜黄素与动脉粥样硬化风险指标(包括颈动脉内膜中层厚度(CIMT))的降低成反比。本研究旨在评估姜黄素对糖尿病血液透析(HD)患者颈动脉内膜厚度(CIMT)和脉搏波速度(PWV)的影响:这项随机、双盲、安慰剂对照试验针对 39 名糖尿病血液透析患者进行。患者被分配接受姜黄素或安慰剂(淀粉)治疗,为期 24 周。姜黄素组(26 人)每天服用 80 毫克姜黄素。在基线和干预 24 周后测量 CIMT 和脉搏波速度水平:干预 24 周后,与安慰剂相比,姜黄素摄入量不会影响左侧(P = 0.83)和右侧(P = 0.47)CIMT 的平均水平、左侧(P = 0.84)和右侧(P = 0.11)CIMT 的最大水平以及脉搏波速度(P = 0.12)。此外,组内差异显示姜黄素组的脉搏波速度平均水平显著降低(P = 0.01)。我们没有观察到姜黄素摄入后C反应蛋白(CRP)浓度有任何明显变化(P = 0.69):结论:与安慰剂相比,姜黄素摄入不会影响左右CIMT的平均水平和左右CIMT的最大水平、脉搏波速度和CRP水平。此外,组内差异表明姜黄素组的脉搏波速度平均水平显著降低。该试验在 www.irct.ir 注册为 http://www.irct.ir:IRCT20200527047584N1.
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Effects of Curcumin Administration on Carotid Intima-Media Thickness and Pulse Wave Velocity in Diabetic Hemodialysis Patients: A Randomized, Double-Blinded, Placebo-Controlled Trial.

Background: Prior studies have reported that curcumin is inversely associated with reduced markers of atherosclerosis risk, including carotid intima-media thickness (CIMT). This study was designed to assess the effects of curcumin on CIMT and pulse wave velocity (PWV) in diabetic hemodialysis (HD) patients.

Methods: This randomized, double-blinded, placebo-controlled trial was conducted on 39 diabetic HD patients. People were assigned to receive curcumin or placebo (starch) for 24 weeks. Individuals in the curcumin group (n = 26) received 80 mg/day. CIMT and PWV levels were taken at baseline and after 24 weeks of intervention.

Results: After 24 weeks of intervention, curcumin intake did not affect mean levels of left (P = 0.83) and right (P = 0.47) CIMT and maximum levels of left (P = 0.84) and right (P = 0.11) CIMT, and PWV (P = 0.12) compared to the placebo. Furthermore, within-group difference demonstrated a significant reduction in mean levels of PWV (P = 0.01) in the curcumin group. We did not observe any significant change in C-reactive protein (CRP) concentrations after curcumin intake (P = 0.69).

Conclusions: Curcumin intake did not affect mean levels of left and right CIMT and maximum levels of left and right CIMT, PWV, and CRP levels compared to the placebo. Additionally, within-group difference demonstrated a significant reduction in mean levels of PWV in the curcumin group.This trial was registered at www.irct.ir as http://www.irct.ir: IRCT20200527047584N1.

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来源期刊
International Journal of Preventive Medicine
International Journal of Preventive Medicine MEDICINE, GENERAL & INTERNAL-
CiteScore
3.20
自引率
4.80%
发文量
107
期刊介绍: International Journal of Preventive Medicine, a publication of Isfahan University of Medical Sciences, is a peer-reviewed online journal with Continuous print on demand compilation of issues published. The journal’s full text is available online at http://www.ijpvmjournal.net. The journal allows free access (Open Access) to its contents and permits authors to self-archive final accepted version of the articles on any OAI-compliant institutional / subject-based repository. The journal will cover technical and clinical studies related to health, ethical and social issues in field of Preventive Medicine. Articles with clinical interest and implications will be given preference.
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