Gabriel Victor Teodoro de Medeiros Marcos, Deymisson Damitene Martins Feitosa, Karina Maia Paiva, Rodrigo Freire Oliveira, Gabriel Sousa da Rocha, Luís Marcos de Medeiros Guerra, Dayane Pessoa de Araújo, Hosana Mirelle Goes, Silva Costa, Lucidio Clebeson de Oliveira, Fausto Pierdoná Guzen, José Edvan de Souza Júnior, Marco Aurélio de Moura Freire, Antonio Carlos Queiroz de Aquino, Paulo Leonardo Araújo de Gois Morais, José Rodolfo Lopes de Paiva Cavalcanti
{"title":"自闭症谱系障碍中基底神经节的体积变化：系统综述。","authors":"Gabriel Victor Teodoro de Medeiros Marcos, Deymisson Damitene Martins Feitosa, Karina Maia Paiva, Rodrigo Freire Oliveira, Gabriel Sousa da Rocha, Luís Marcos de Medeiros Guerra, Dayane Pessoa de Araújo, Hosana Mirelle Goes, Silva Costa, Lucidio Clebeson de Oliveira, Fausto Pierdoná Guzen, José Edvan de Souza Júnior, Marco Aurélio de Moura Freire, Antonio Carlos Queiroz de Aquino, Paulo Leonardo Araújo de Gois Morais, José Rodolfo Lopes de Paiva Cavalcanti","doi":"10.1002/jdn.10322","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Introduction</h3>\n \n <p>Recent research indicates that some brain structures show alterations in conditions such as Autism Spectrum Disorder (ASD). Among them, are the basal ganglia that are involved in motor, cognitive and behavioral neural circuits.</p>\n </section>\n \n <section>\n \n <h3> Objective</h3>\n \n <p>Review the literature that describes possible volumetric alterations in the basal ganglia of individuals with ASD and the impacts that these changes have on the severity of the condition.</p>\n </section>\n \n <section>\n \n <h3> Methodology</h3>\n \n <p>This systematic review was registered in the design and reported according to the PRISMA Items and registered in PROSPERO (CRD42023394787). The study analyzed data from published clinical, case-contemplate, and cohort trials. The following databases were consulted: PubMed, Embase, Scopus, and Cochrane Central Register of Controlled Trials, using the Medical Subject Titles (MeSH) “Autism Spectrum Disorder” and “Basal Ganglia”. The last search was carried out on February 28, 2023.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Thirty-five eligible articles were collected, analyzed, and grouped according to the levels of alterations.</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>The present study showed important volumetric alterations in the basal ganglia in ASD. However, the examined studies have methodological weaknesses that do not allow generalization and correlation with ASD manifestations.</p>\n </section>\n </div>","PeriodicalId":13914,"journal":{"name":"International Journal of Developmental Neuroscience","volume":"84 3","pages":"163-176"},"PeriodicalIF":1.7000,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Volumetric alterations in the basal ganglia in autism Spectrum disorder: A systematic review\",\"authors\":\"Gabriel Victor Teodoro de Medeiros Marcos, Deymisson Damitene Martins Feitosa, Karina Maia Paiva, Rodrigo Freire Oliveira, Gabriel Sousa da Rocha, Luís Marcos de Medeiros Guerra, Dayane Pessoa de Araújo, Hosana Mirelle Goes, Silva Costa, Lucidio Clebeson de Oliveira, Fausto Pierdoná Guzen, José Edvan de Souza Júnior, Marco Aurélio de Moura Freire, Antonio Carlos Queiroz de Aquino, Paulo Leonardo Araújo de Gois Morais, José Rodolfo Lopes de Paiva Cavalcanti\",\"doi\":\"10.1002/jdn.10322\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Introduction</h3>\\n \\n <p>Recent research indicates that some brain structures show alterations in conditions such as Autism Spectrum Disorder (ASD). 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Volumetric alterations in the basal ganglia in autism Spectrum disorder: A systematic review
Introduction
Recent research indicates that some brain structures show alterations in conditions such as Autism Spectrum Disorder (ASD). Among them, are the basal ganglia that are involved in motor, cognitive and behavioral neural circuits.
Objective
Review the literature that describes possible volumetric alterations in the basal ganglia of individuals with ASD and the impacts that these changes have on the severity of the condition.
Methodology
This systematic review was registered in the design and reported according to the PRISMA Items and registered in PROSPERO (CRD42023394787). The study analyzed data from published clinical, case-contemplate, and cohort trials. The following databases were consulted: PubMed, Embase, Scopus, and Cochrane Central Register of Controlled Trials, using the Medical Subject Titles (MeSH) “Autism Spectrum Disorder” and “Basal Ganglia”. The last search was carried out on February 28, 2023.
Results
Thirty-five eligible articles were collected, analyzed, and grouped according to the levels of alterations.
Conclusion
The present study showed important volumetric alterations in the basal ganglia in ASD. However, the examined studies have methodological weaknesses that do not allow generalization and correlation with ASD manifestations.
期刊介绍：
International Journal of Developmental Neuroscience publishes original research articles and critical review papers on all fundamental and clinical aspects of nervous system development, renewal and regeneration, as well as on the effects of genetic and environmental perturbations of brain development and homeostasis leading to neurodevelopmental disorders and neurological conditions. Studies describing the involvement of stem cells in nervous system maintenance and disease (including brain tumours), stem cell-based approaches for the investigation of neurodegenerative diseases, roles of neuroinflammation in development and disease, and neuroevolution are also encouraged. Investigations using molecular, cellular, physiological, genetic and epigenetic approaches in model systems ranging from simple invertebrates to human iPSC-based 2D and 3D models are encouraged, as are studies using experimental models that provide behavioural or evolutionary insights. The journal also publishes Special Issues dealing with topics at the cutting edge of research edited by Guest Editors appointed by the Editor in Chief. A major aim of the journal is to facilitate the transfer of fundamental studies of nervous system development, maintenance, and disease to clinical applications. The journal thus intends to disseminate valuable information for both biologists and physicians. International Journal of Developmental Neuroscience is owned and supported by The International Society for Developmental Neuroscience (ISDN), an organization of scientists interested in advancing developmental neuroscience research in the broadest sense.
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