母乳喂养早产儿与标准强化方案和可调强化方案的生长结果比较

IF 2.1 3区 医学 Q2 OBSTETRICS & GYNECOLOGY
Breastfeeding Medicine Pub Date : 2024-05-01 Epub Date: 2024-03-15 DOI:10.1089/bfm.2024.0001
Meera Khorana, Sareeporn Lamprasertkul, Suppawat Boonkasidecha
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引用次数: 0

摘要

背景:人乳(HM)通常采用标准强化(STD)方法进行强化,以改善早产儿的营养状况。然而,蛋白质成分可能仍然不足。可进一步强化母乳中的蛋白质,以改善标准强化。目标:主要目的是比较喂食 STD 配方奶粉的早产新生儿与喂食可调节强化配方奶粉 (ADJ) 的早产新生儿在体重(克/天、克/公斤/天)、身长和头围(毫米/天)方面的变化。研究方法本研究是一项前瞻性、单盲、随机对照研究,研究对象是胎龄为 Results 的早产儿:30 名早产儿完成了研究,并被随机分为两组,每组 15 人。两组婴儿的基线特征、总液体和能量摄入量相似。与 STD 组相比,ADJ 组婴儿的体重增长(36.46 ± 6.09 克/天 vs. 25.78 ± 8.81 克/天;p = 0.001)和身长增长(1.93 ± 0.57 毫米/天 vs. 1.12 ± 0.64 毫米/天;p = 0.001)显著高于 STD 组。蛋白质摄入量与体重(r = 0.632,p < 0.001)和体长增长(r = 0.577,p = 0.001)均有明显相关性;但能量摄入量、体积摄入量与生长结果之间没有相关性。结论用 ADJ 喂养的早产儿的体重和身长增长明显高于用 STD 喂养的早产儿,这表明额外的蛋白质摄入量可能在生长过程中发挥着重要作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Comparison of Growth Outcomes Between Human Milk-Fed Preterm Infants on Standard Versus Adjustable Fortification Protocols.

Background: Human milk (HM) is usually fortified using standard fortification (STD) to improve nutrition of preterm infants. However, the protein component may still be insufficient. HM could be further fortified with additional protein to improve STD. Objective: The primary objective was to compare changes in body weight (g/day, g/kg/day), length, and head circumference (mm/day) between preterm neonates fed HM with STD and those fed HM with adjustable fortification (ADJ). Methods: This study was a prospective, single-blinded, randomized controlled study in preterm infants of gestational age <32 weeks and weighing ≤1,800 g, admitted to the neonatal unit of the Queen Sirikit National Institute of Child Health. Once the infants received full HM feed with STD at 24 kcal/oz, they were randomized to either continue with STD or with ADJ group by adding additional protein to the STD and making further protein adjustments based on the blood urea nitrogen levels. Results: Thirty preterm infants completed the study and were randomized into two groups of 15 each. The baseline characteristics, total fluid, and energy intake were similar. Compared with the STD group, infants in the ADJ group exhibited significantly greater weight gain (36.46 ± 6.09 vs. 25.78 ± 8.81 g/day; p = 0.001) and greater length gain (1.93 ± 0.57 vs. 1.12 ± 0.64 mm/day; p = 0.001). Protein intake significantly correlated with both weight (r = 0.632, p < 0.001) and length gain (r = 0.577, p = 0.001); however, no correlation was found between energy intake, volume intake, and growth outcomes. Conclusion: Preterm infants fed with ADJ had significantly higher weight and length gains than those fed with STD, suggesting that additional protein intake may play an important role in growth.

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来源期刊
Breastfeeding Medicine
Breastfeeding Medicine OBSTETRICS & GYNECOLOGY-PEDIATRICS
CiteScore
4.20
自引率
11.10%
发文量
130
审稿时长
6-12 weeks
期刊介绍: Breastfeeding Medicine provides unparalleled peer-reviewed research, protocols, and clinical applications to ensure optimal care for mother and infant. The Journal answers the growing demand for evidence-based research and explores the immediate and long-term outcomes of breastfeeding, including its epidemiologic, physiologic, and psychological benefits. It is the exclusive source of the Academy of Breastfeeding Medicine protocols. Breastfeeding Medicine coverage includes: Breastfeeding recommendations and protocols Health consequences of artificial feeding Physiology of lactation and biochemistry of breast milk Optimal nutrition for the breastfeeding mother Breastfeeding indications and contraindications Managing breastfeeding discomfort, pain, and other complications Breastfeeding the premature or sick infant Breastfeeding in the chronically ill mother Management of the breastfeeding mother on medication Infectious disease transmission through breast milk and breastfeeding The collection and storage of human milk and human milk banking Measuring the impact of being a “baby-friendly” hospital Cultural competence and cultural sensitivity International public health issues including social and economic issues.
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