儿童偶然性胆总管扩张的临床意义：单个医疗中心的十年经验

IF 4.1 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biomedical Journal Pub Date : 2024-03-12 DOI:10.1016/j.bj.2024.100717

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引用次数: 0

摘要

背景：随着腹部超声波检查（US）的广泛应用，偶然发现胆总管（CBD）扩张在儿科人群中很常见。本研究调查了在 US 检查中没有胆道症状、黄疸或致病病变的儿童中出现总胆管扩张的原因和临床意义：我们回顾性研究了2013年7月至2023年6月期间CBD扩张的儿童患者。所有病例均通过腹部超声检查发现。我们分析了患者的临床表现、实验室数据、诊断、基础疾病和临床过程：在总共 687 例入选患者中，338 例符合纳入标准（90 例为肝胆管扩张组，248 例为 CBD 扩张组）。在接受定期US检查的128例偶然CBD扩张患者中，91例（71.1%）在随访期间症状得到缓解。在未缓解组中，肝内导管扩张患者的比例明显更高（P = 0.038）。与胃肠道组和感染组相比，一般健康检查组的 CBD 直径明显较小。相关性分析发现，CBD直径在3.24毫米（所有组）和2.51毫米（婴儿组）时为缓解下降的起点：结论：大多数偶然CBD扩张的儿童没有肝胆功能异常或其他声像图异常。结论：大多数偶然CBD扩张的患儿没有肝胆功能异常或其他声像图异常，他们通常没有症状，临床过程也很顺利。

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Clinical significance of incidental common bile duct dilatation in children: A 10-year single medical center experience

Background

With the widespread use of abdominal ultrasonography (US), incidental detection of common bile duct (CBD) dilatation is common in pediatric populations. This study investigated the causes and clinical significance of CBD dilatation in children without biliary symptoms, jaundice, or causative lesions in US.

Methods

We retrospectively reviewed pediatric patients with CBD dilatation from July 2013 to June 2023. All cases were detected via abdominal US. We analyzed the patients’ clinical manifestations, laboratory data, diagnosis, underlying diseases, and clinical course.

Results

In a total of 687 patients enrolled, 338 met inclusion criteria (90 in hepatobiliary, 248 in CBD dilatation group). Of 128 patients with incidental CBD dilatation who underwent regular US examinations, 91 (71.1%) experienced resolution during follow-up. The proportion of patients with intrahepatic duct dilatation was significantly higher in the non-resolution group (p = 0.038). General health examination group had significant smaller CBD diameter compared to the gastrointestinal and infection groups. Correlation analysis found starting point of resolution decline at 3.24 mm (all-inclusive) and 2.51 mm (infant group) CBD diameter.

Conclusions

Most children with incidental CBD dilatation did not have abnormal hepatobiliary function or other sonographic abnormalities. They usually remained asymptomatic and experienced uneventful clinical courses.

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来源期刊

Biomedical Journal Medicine-General Medicine

CiteScore

11.60

自引率

1.80%

发文量

128

审稿时长

42 days

期刊介绍： Biomedical Journal publishes 6 peer-reviewed issues per year in all fields of clinical and biomedical sciences for an internationally diverse authorship. Unlike most open access journals, which are free to readers but not authors, Biomedical Journal does not charge for subscription, submission, processing or publication of manuscripts, nor for color reproduction of photographs. Clinical studies, accounts of clinical trials, biomarker studies, and characterization of human pathogens are within the scope of the journal, as well as basic studies in model species such as Escherichia coli, Caenorhabditis elegans, Drosophila melanogaster, and Mus musculus revealing the function of molecules, cells, and tissues relevant for human health. However, articles on other species can be published if they contribute to our understanding of basic mechanisms of biology. A highly-cited international editorial board assures timely publication of manuscripts. Reviews on recent progress in biomedical sciences are commissioned by the editors.