氧化铁纳米颗粒:从神经保护到神经退化的深入分析综述

IF 3.5 Q3 ENGINEERING, ENVIRONMENTAL
Ruchika Agarwal, Satadal Adhikary, Suchandra Bhattacharya, Sohini Goswami, Dipsikha Roy, Sohini Dutta, Abhratanu Ganguly, Sayantani Nanda and Prem Rajak
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引用次数: 0

摘要

空气污染是神经系统疾病的主要风险因素。室内和室外灰尘中都含有不同种类的纳米级氧化铁。由于氧化铁纳米粒子(IONPs)体积小,具有独特的化学物理特性,因此可通过细胞内路径聚集在细胞胞浆内。此外,它们还能穿过血脑屏障,侵入大脑皮层组织,损害神经元功能。因此,分析 IONPs 对中枢神经系统(CNS)结构和功能的影响是必不可少的。为此,我们按照 PRISMA 指南对已发表的文献进行了系统研究。文献检索通过三个科学数据库进行:ScienceDirect、PubMed 和 Google scholar。对截至 2023 年 8 月发表的原创文章进行了相关性筛选。对相关文献的分析表明,IONPs 正被用于药物输送系统和中枢神经系统相关疾病的诊断,有利于神经保护。然而,从空气和其他来源吸入 IONPs 会导致铁在神经元组织中过度积累,从而导致神经元信号紊乱和神经退行性疾病的发生。因此,必须监测和控制环境中 IONP 的含量,以消除对神经系统的不利影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Iron oxide nanoparticles: a narrative review of in-depth analysis from neuroprotection to neurodegeneration

Iron oxide nanoparticles: a narrative review of in-depth analysis from neuroprotection to neurodegeneration

Air pollution is a major risk factor for neurological disorders. Both indoor and outdoor dusts comprise different types of iron oxides in the nano-scale range. Due to their small size and unique physico-chemical properties, iron oxide nanoparticles (IONPs) adopt the intracellular path to agglomerate inside the cell cytoplasm. Moreover, they can cross the blood–brain barrier to invade cortical tissues in the brain and impair neuronal functions. Hence, analysis of the effects of IONPs on the Central Nervous System (CNS) structure and functions is indispensable from medical perspective. A literature search was performed using three scientific databases: ScienceDirect, PubMed, and Google Scholar. Articles published till December, 2023 were screened for their relevancy. Analyses of the appropriate literature have revealed that IONPs are being employed in drug delivery systems and diagnosis of CNS-related ailments that favor neuroprotection. However, the inhalation of IONPs from air and other sources can lead to excessive accumulation of iron in the neuronal tissues, leading to a disturbance in neuronal signaling and augmenting the onset of neurodegenerative disorders. Therefore, it is essential to monitor and control the abundance of IONPs in the environment to combat adverse impacts on the human nervous system.

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