Feasibility of Active Surveillance in Patients with Clinically T1b Papillary Thyroid Carcinoma ≤1.5 cm in Preoperative Ultrasonography: MASTER Study

Objective: Active surveillance (AS) is generally accepted as an alternative to immediate surgery for papillary thyroid carcinoma (PTC) measuring ≤1.0 cm (cT1a) without risk factors. This study investigated the clinicopathologic characteristics of PTCs measuring ≤2.0 cm without cervical lymph node metastasis (cT1N0) by tumor size group to assess the feasibility of AS for PTCs between 1.0 cm and 1.5 cm (cT1b^≤1.5). Design: This study enrolled clinically T1N0 patients with preoperative ultrasonography information (N=935) from a cohort of 1259 patients who underwent lobectomy and were finally diagnosed with PTC from June 2020 to March 2022. Results: The cT1b≤1.5 group (N=171; 18.3 %) exhibited more lymphatic invasion and occult central lymph node (LN) metastasis with higher metastatic LN ratio than the cT1a group (N=719; 76.9 %). However, among patients aged 55 years or older, there were no significant differences in occult central LN metastasis and metastatic LN ratio between the cT1a, cT1b^≤1.5, and cT1b^>1.5 groups. Multivariate regression analyses revealed that occult central LN metastasis was associated with age, sex, tumor size, extrathyroidal extension, and lymphatic invasion in patients under 55, while in those aged 55 or older, it was associated only with age and lymphatic invasion. Conclusion: For PTC patients aged 55 years or older with cT1b^≤1.5, AS could be a viable option due to the absence of a significant relationship between tumor size and occult central LN.