Yongchun Cui , Xiaobing Zheng , Shuo Wang , Jianye Zhou , Guangxin Yue , Peng Peng , Qiuju Li , Jubo Li , Yue Li , Jiafei Luo , Qi Zhang , Xue Zhang , Yongjian Li , Xin Wang
{"title":"评估超声波辅助绵羊人工心脏泵溶栓的安全性和有效性","authors":"Yongchun Cui , Xiaobing Zheng , Shuo Wang , Jianye Zhou , Guangxin Yue , Peng Peng , Qiuju Li , Jubo Li , Yue Li , Jiafei Luo , Qi Zhang , Xue Zhang , Yongjian Li , Xin Wang","doi":"10.1016/j.bbe.2024.02.003","DOIUrl":null,"url":null,"abstract":"<div><p>Thrombosis is a major and serious complication in patients with artificial heart pump assist device (HPAD). There is an urgent need for an efficient and safe method to solve the clinical challenge. We have developed a new type of ultrasound integrated heart pump assist device (uHPAD) with a pair of ultrasonic transducer rings installed around the pump. Based on the <em>in-vitro</em> experiments, the sonothrombolysis protocol was determined. Then, <em>in-vivo</em> experiments were performed on sheep to evaluate the efficacy and safety of the novel uHPAD. It is found that the ultrasound assisted thrombolysis with the drug-loaded microbubbles can accelerate the dissolution of the thrombus in the pump, while have no significant negative effect on blood cell components, coagulation-hemolysis system, and the structure and function of main organs. The ultrasound assisted thrombolysis is demonstrated to be a promising method to solve the clinical problem of thrombosis in the HPAD.</p></div>","PeriodicalId":55381,"journal":{"name":"Biocybernetics and Biomedical Engineering","volume":"44 2","pages":"Pages 277-285"},"PeriodicalIF":5.3000,"publicationDate":"2024-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0208521624000093/pdfft?md5=424e0ba33dbbd811d478d1a145588826&pid=1-s2.0-S0208521624000093-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Evaluation on safety and efficacy of ultrasound assisted thrombolysis in a sheep artificial heart pump\",\"authors\":\"Yongchun Cui , Xiaobing Zheng , Shuo Wang , Jianye Zhou , Guangxin Yue , Peng Peng , Qiuju Li , Jubo Li , Yue Li , Jiafei Luo , Qi Zhang , Xue Zhang , Yongjian Li , Xin Wang\",\"doi\":\"10.1016/j.bbe.2024.02.003\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Thrombosis is a major and serious complication in patients with artificial heart pump assist device (HPAD). There is an urgent need for an efficient and safe method to solve the clinical challenge. We have developed a new type of ultrasound integrated heart pump assist device (uHPAD) with a pair of ultrasonic transducer rings installed around the pump. Based on the <em>in-vitro</em> experiments, the sonothrombolysis protocol was determined. Then, <em>in-vivo</em> experiments were performed on sheep to evaluate the efficacy and safety of the novel uHPAD. It is found that the ultrasound assisted thrombolysis with the drug-loaded microbubbles can accelerate the dissolution of the thrombus in the pump, while have no significant negative effect on blood cell components, coagulation-hemolysis system, and the structure and function of main organs. The ultrasound assisted thrombolysis is demonstrated to be a promising method to solve the clinical problem of thrombosis in the HPAD.</p></div>\",\"PeriodicalId\":55381,\"journal\":{\"name\":\"Biocybernetics and Biomedical Engineering\",\"volume\":\"44 2\",\"pages\":\"Pages 277-285\"},\"PeriodicalIF\":5.3000,\"publicationDate\":\"2024-03-13\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S0208521624000093/pdfft?md5=424e0ba33dbbd811d478d1a145588826&pid=1-s2.0-S0208521624000093-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Biocybernetics and Biomedical Engineering\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0208521624000093\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"ENGINEERING, BIOMEDICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biocybernetics and Biomedical Engineering","FirstCategoryId":"5","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0208521624000093","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENGINEERING, BIOMEDICAL","Score":null,"Total":0}
Evaluation on safety and efficacy of ultrasound assisted thrombolysis in a sheep artificial heart pump
Thrombosis is a major and serious complication in patients with artificial heart pump assist device (HPAD). There is an urgent need for an efficient and safe method to solve the clinical challenge. We have developed a new type of ultrasound integrated heart pump assist device (uHPAD) with a pair of ultrasonic transducer rings installed around the pump. Based on the in-vitro experiments, the sonothrombolysis protocol was determined. Then, in-vivo experiments were performed on sheep to evaluate the efficacy and safety of the novel uHPAD. It is found that the ultrasound assisted thrombolysis with the drug-loaded microbubbles can accelerate the dissolution of the thrombus in the pump, while have no significant negative effect on blood cell components, coagulation-hemolysis system, and the structure and function of main organs. The ultrasound assisted thrombolysis is demonstrated to be a promising method to solve the clinical problem of thrombosis in the HPAD.
期刊介绍：
Biocybernetics and Biomedical Engineering is a quarterly journal, founded in 1981, devoted to publishing the results of original, innovative and creative research investigations in the field of Biocybernetics and biomedical engineering, which bridges mathematical, physical, chemical and engineering methods and technology to analyse physiological processes in living organisms as well as to develop methods, devices and systems used in biology and medicine, mainly in medical diagnosis, monitoring systems and therapy. The Journal''s mission is to advance scientific discovery into new or improved standards of care, and promotion a wide-ranging exchange between science and its application to humans.
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