Ke’Koa CDH Wells , Nawwaf Kharma , Brandon B. Jaunky , Kaiyu Nie , Gabriel Aguiar-Tawil , Daniel Berry
{"title":"BioCloneBot:多功能、低成本、开源自动液体处理机","authors":"Ke’Koa CDH Wells , Nawwaf Kharma , Brandon B. Jaunky , Kaiyu Nie , Gabriel Aguiar-Tawil , Daniel Berry","doi":"10.1016/j.ohx.2024.e00516","DOIUrl":null,"url":null,"abstract":"<div><p>Liquid handler systems can provide significant benefits to researchers by automating laboratory work, however, their unaffordable price provides a steep barrier to entry. Therefore, we provide the BioCloneBot, a versatile, low-cost, and open-source automated liquid handler. This system can be easily built with 3D-printed parts and readily available commercial components. The BioCloneBot is highly adaptive to user needs and facilitates various liquid handling tasks in research and diagnostics. Its user-friendly interface and programmable nature make it suitable for a wide range of applications, from small-scale experiments to larger laboratory setups. By utilizing BioCloneBot, researchers and scientists can streamline their liquid handling processes without the financial constraints posed by traditional systems. In this paper, we detail the design, construction, and validation of BioCloneBot, showcasing its precise control, accuracy, and repeatability in various liquid handling tasks. The open-source nature of the system encourages collaboration and customization, enabling researchers to contribute and adapt the technology to specific experimental requirements.</p></div>","PeriodicalId":37503,"journal":{"name":"HardwareX","volume":null,"pages":null},"PeriodicalIF":2.0000,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2468067224000105/pdfft?md5=a0cb106f75004b6841e4acba7046051d&pid=1-s2.0-S2468067224000105-main.pdf","citationCount":"0","resultStr":"{\"title\":\"BioCloneBot: A versatile, low-cost, and open-source automated liquid handler\",\"authors\":\"Ke’Koa CDH Wells , Nawwaf Kharma , Brandon B. Jaunky , Kaiyu Nie , Gabriel Aguiar-Tawil , Daniel Berry\",\"doi\":\"10.1016/j.ohx.2024.e00516\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Liquid handler systems can provide significant benefits to researchers by automating laboratory work, however, their unaffordable price provides a steep barrier to entry. Therefore, we provide the BioCloneBot, a versatile, low-cost, and open-source automated liquid handler. This system can be easily built with 3D-printed parts and readily available commercial components. The BioCloneBot is highly adaptive to user needs and facilitates various liquid handling tasks in research and diagnostics. Its user-friendly interface and programmable nature make it suitable for a wide range of applications, from small-scale experiments to larger laboratory setups. By utilizing BioCloneBot, researchers and scientists can streamline their liquid handling processes without the financial constraints posed by traditional systems. In this paper, we detail the design, construction, and validation of BioCloneBot, showcasing its precise control, accuracy, and repeatability in various liquid handling tasks. The open-source nature of the system encourages collaboration and customization, enabling researchers to contribute and adapt the technology to specific experimental requirements.</p></div>\",\"PeriodicalId\":37503,\"journal\":{\"name\":\"HardwareX\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.0000,\"publicationDate\":\"2024-02-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S2468067224000105/pdfft?md5=a0cb106f75004b6841e4acba7046051d&pid=1-s2.0-S2468067224000105-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"HardwareX\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2468067224000105\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"ENGINEERING, ELECTRICAL & ELECTRONIC\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"HardwareX","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2468067224000105","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ENGINEERING, ELECTRICAL & ELECTRONIC","Score":null,"Total":0}
引用次数: 0
摘要
液体处理系统可使实验室工作自动化,从而为研究人员带来巨大的益处,然而,其难以承受的价格却为进入该系统设置了高门槛。因此,我们提供了 BioCloneBot,一种多功能、低成本、开源的自动液体处理机。该系统可使用 3D 打印部件和现成的商用组件轻松构建。BioCloneBot 可高度适应用户需求,为研究和诊断中的各种液体处理任务提供便利。它的用户友好界面和可编程特性使其适用于从小规模实验到大型实验室装置的广泛应用。通过使用 BioCloneBot,研究人员和科学家可以简化液体处理流程,而不受传统系统带来的经济限制。在本文中,我们详细介绍了 BioCloneBot 的设计、构造和验证,展示了它在各种液体处理任务中的精确控制、准确性和可重复性。该系统的开源性质鼓励合作和定制,使研究人员能够贡献技术并使其适应特定的实验要求。
BioCloneBot: A versatile, low-cost, and open-source automated liquid handler
Liquid handler systems can provide significant benefits to researchers by automating laboratory work, however, their unaffordable price provides a steep barrier to entry. Therefore, we provide the BioCloneBot, a versatile, low-cost, and open-source automated liquid handler. This system can be easily built with 3D-printed parts and readily available commercial components. The BioCloneBot is highly adaptive to user needs and facilitates various liquid handling tasks in research and diagnostics. Its user-friendly interface and programmable nature make it suitable for a wide range of applications, from small-scale experiments to larger laboratory setups. By utilizing BioCloneBot, researchers and scientists can streamline their liquid handling processes without the financial constraints posed by traditional systems. In this paper, we detail the design, construction, and validation of BioCloneBot, showcasing its precise control, accuracy, and repeatability in various liquid handling tasks. The open-source nature of the system encourages collaboration and customization, enabling researchers to contribute and adapt the technology to specific experimental requirements.
HardwareXEngineering-Industrial and Manufacturing Engineering
CiteScore
4.10
自引率
18.20%
发文量
124
审稿时长
24 weeks
期刊介绍:
HardwareX is an open access journal established to promote free and open source designing, building and customizing of scientific infrastructure (hardware). HardwareX aims to recognize researchers for the time and effort in developing scientific infrastructure while providing end-users with sufficient information to replicate and validate the advances presented. HardwareX is open to input from all scientific, technological and medical disciplines. Scientific infrastructure will be interpreted in the broadest sense. Including hardware modifications to existing infrastructure, sensors and tools that perform measurements and other functions outside of the traditional lab setting (such as wearables, air/water quality sensors, and low cost alternatives to existing tools), and the creation of wholly new tools for either standard or novel laboratory tasks. Authors are encouraged to submit hardware developments that address all aspects of science, not only the final measurement, for example, enhancements in sample preparation and handling, user safety, and quality control. The use of distributed digital manufacturing strategies (e.g. 3-D printing) is encouraged. All designs must be submitted under an open hardware license.