将视网膜电图作为筛查工具，评估维加溴铵诱发的婴儿痉挛症患儿视网膜毒性。

IF 1 4区医学 Q4 OPHTHALMOLOGY

Journal of Pediatric Ophthalmology & Strabismus Pub Date : 2024-07-01 Epub Date: 2024-03-14 DOI:10.3928/01913913-20240215-01

Suruthi Nagarajan, Rajesh Prabu, Nikulaa Parachuri, Mithun Thulasidas

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引用次数: 0

摘要

目的：评估视网膜电图（ERG）作为筛查婴儿痉挛症患儿维加巴曲林诱发视网膜毒性的工具的实用性：这是一项观察性队列研究，研究对象包括接受维格巴曲林治疗的婴儿痉挛症患儿。使用 RETeval 系统（LKC Technologies）在开始使用维格巴特林之前的 6 个月和 1 年进行 30Hz 闪烁电位 ERG 基线检查。结果研究共纳入了 11 名儿童。婴儿痉挛症最常见的病因是结节性硬化症（36.4%），其次是韦斯特综合征（27.3%）。患儿的平均年龄为 7.14 ± 2.9 个月，年龄范围为 3 至 16 个月。随访 6 个月和 12 个月时，振幅的平均差异分别为 3.21 ± 2.45 和 5.72 ± 4.18 µV（P < .001）。11名儿童中有8名（72.7%）出现了维格巴曲林引起的视网膜毒性，所有8名儿童接受维格巴曲林治疗的时间都超过了6个月：结论：ERG 可用于监测婴儿痉挛症患儿维格巴曲林诱发的视网膜毒性。维加巴曲林诱发的视网膜毒性与治疗时间长短有关，而与累积剂量无关。[儿童眼科斜视杂志。20xx;x(x):xxx-xxx.

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Electroretinogram as a Screening Tool to Assess Vigabatrin-Induced Retinal Toxicity in Children With Infantile Spasms.

Purpose: To assess the utility of electroretinogram (ERG) as a screening tool for vigabatrin-induced retinal toxicity in children with infantile spasms.

Methods: This was an observational cohort study including children with infantile spasms receiving treatment with vigabatrin. A 30-Hz flicker potential ERG, using the RETeval system (LKC Technologies), was done at baseline before starting vigabatrin at 6 months and 1 year. The amplitudes were recorded.

Results: Eleven children were included in the study. The most common etiologic factor for infantile spasms was tuberous sclerosis (36.4%) followed by West syndrome (27.3%). The mean age of the children was 7.14 ± 2.9 months, with a range of 3 to 16 months. The mean difference in amplitude was 3.21 ± 2.45 and 5.72 ± 4.18 µV at 6 and 12 months follow-up, respectively (P < .001). Eight of the 11 children (72.7%) showed vigabatrin-induced retinal toxicity, and all 8 children were receiving vigabatrin for more than 6 months.

Conclusions: ERG can be used for vigabatrin-induced retinal toxicity monitoring in children with infantile spasms. Vigabatrin-induced retinal toxicity is related to the duration of treatment rather than cumulative dosage. [J Pediatr Ophthalmol Strabismus. 2024;61(4):273-278.].

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来源期刊

Journal of Pediatric Ophthalmology & Strabismus 医学-小儿科

CiteScore

1.80

自引率

8.30%

发文量

115

审稿时长

>12 weeks

期刊介绍： The Journal of Pediatric Ophthalmology & Strabismus is a bimonthly peer-reviewed publication for pediatric ophthalmologists. The Journal has published original articles on the diagnosis, treatment, and prevention of eye disorders in the pediatric age group and the treatment of strabismus in all age groups for over 50 years.