间质性肺病当天 CT 定量的测量变异性:一项多中心前瞻性研究

IF 3.8 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Jong Hyuk Lee, Kum Ju Chae, Jimyung Park, Sun Mi Choi, Myoung-Jin Jang, Eui Jin Hwang, Gong Yong Jin, Jin Mo Goo
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引用次数: 0

摘要

目的 根据两次当天的 CT 扫描结果,研究间质性肺病(ILD)的定量 CT(QCT)测量变异性。材料和方法 在 2022 年 3 月至 10 月期间,这项多中心前瞻性研究招募了患有 ILD 的参与者。参与者在几分钟内接受了两次当天的 CT 扫描。基于深度学习的纹理分析软件用于分割 ILD 特征。纤维化程度被定义为网状不透明和蜂窝状囊肿的总和。扫描之间的测量变异性通过布兰-阿尔特曼(Bland-Altman)分析法进行评估,以确定绝对和相对差异以及 95% 的一致性限(LOA)。使用多变量线性混合效应模型分析了纤维化程度对变异性的影响,同时对肺容积进行了调整。八位读者对随机抽取的 30 个样本进行了有 QCT 信息和无 QCT 信息的 ILD 纤维化稳定性评估。结果 65 名参与者参加了这项研究(平均年龄为 68.7 岁 ± 10 [SD];男性 47 [72%],女性 18 [28%])。在两次当天的 CT 扫描之间,定量纤维化程度的平均绝对值和相对值差异的 95% LOA 分别为 -0.9% 至 1.0% 和 -14.8% 至 16.1%。然而,在不同重建参数的CT扫描之间,这些变异性增加到95% LOA,分别为-11.3%至3.9%和-123.1%至18.4%。多变量分析显示,绝对差异与基线纤维化程度无关(P = .09),但相对差异呈负相关(β = -0.252,P < .001)。QCT 结果提高了读者解读 ILD 纤维化稳定性的特异性(91.7% vs 94.6%,P = .02)。结论 在当天的 CT 扫描中,QCT 测量 ILD 纤维化程度的绝对变异性为 1%。关键词CT,CT-定量,胸部,肺,肺部疾病,间质性,肺纤维化,诊断,计算机辅助,诊断成像 本文有补充材料。© RSNA, 2024.
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Measurement Variability of Same-Day CT Quantification of Interstitial Lung Disease: A Multicenter Prospective Study.

Purpose To investigate quantitative CT (QCT) measurement variability in interstitial lung disease (ILD) on the basis of two same-day CT scans. Materials and Methods Participants with ILD were enrolled in this multicenter prospective study between March and October 2022. Participants underwent two same-day CT scans at an interval of a few minutes. Deep learning-based texture analysis software was used to segment ILD features. Fibrosis extent was defined as the sum of reticular opacity and honeycombing cysts. Measurement variability between scans was assessed with Bland-Altman analyses for absolute and relative differences with 95% limits of agreement (LOA). The contribution of fibrosis extent to variability was analyzed using a multivariable linear mixed-effects model while adjusting for lung volume. Eight readers assessed ILD fibrosis stability with and without QCT information for 30 randomly selected samples. Results Sixty-five participants were enrolled in this study (mean age, 68.7 years ± 10 [SD]; 47 [72%] men, 18 [28%] women). Between two same-day CT scans, the 95% LOA for the mean absolute and relative differences of quantitative fibrosis extent were -0.9% to 1.0% and -14.8% to 16.1%, respectively. However, these variabilities increased to 95% LOA of -11.3% to 3.9% and -123.1% to 18.4% between CT scans with different reconstruction parameters. Multivariable analysis showed that absolute differences were not associated with the baseline extent of fibrosis (P = .09), but the relative differences were negatively associated (β = -0.252, P < .001). The QCT results increased readers' specificity in interpreting ILD fibrosis stability (91.7% vs 94.6%, P = .02). Conclusion The absolute QCT measurement variability of fibrosis extent in ILD was 1% in same-day CT scans. Keywords: CT, CT-Quantitative, Thorax, Lung, Lung Diseases, Interstitial, Pulmonary Fibrosis, Diagnosis, Computer Assisted, Diagnostic Imaging Supplemental material is available for this article. © RSNA, 2024.

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