Uswatun Hasanah, Purwo Sri Rejeki, Citrawati Dyah Kencono Wungu, Adi Pranoto, Nabilah Izzatunnisa, Ilham Rahmanto, Shariff Halim
{"title":"高强度综合运动对提高肥胖妇女血清鸢尾素和白细胞介素 6 水平的效果最好。","authors":"Uswatun Hasanah, Purwo Sri Rejeki, Citrawati Dyah Kencono Wungu, Adi Pranoto, Nabilah Izzatunnisa, Ilham Rahmanto, Shariff Halim","doi":"10.1515/jbcpp-2023-0150","DOIUrl":null,"url":null,"abstract":"<p><strong>Objectives: </strong>Lifestyle, overnutrition, socioeconomic status, environmental conditions, and genetics are factors that cause obesity. Lifestyle modification with a nonpharmacological approach based on physical exercise is the starting point in overcoming obesity. However, physical exercise with the appropriate and effective intensity for obese subjects is still debated. Therefore, this study aims to prove the effect of intensity differences with aerobic-resistance combination exercise on increasing irisin and IL-6 levels in obese women.</p><p><strong>Methods: </strong>A total of 32 obese women were selected as subjects and administered the interventions of low-intensity combination exercise (Q<sub>2</sub>), moderate-intensity combination exercise (Q<sub>3</sub>), and high-intensity combination exercise (Q<sub>4</sub>). ELISA was used to measure irisin and IL-6 levels in all samples. Statistical analysis used one-way ANOVA and Turkey's-Honest Significant Difference (HSD) post hoc test.</p><p><strong>Results: </strong>The mean Δ IL-6 levels in the control groups (Q<sub>1</sub>), Q<sub>2</sub>, Q<sub>3</sub>, and Q<sub>4</sub> were 0.27 ± 2.54, 2.07 ± 2.55, 5.99 ± 6.25, and 7.98 ± 2.82 pg/mL with (p=0.015). The mean Δ irisin levels were 0.06 ± 0.81 ng/mL in Q<sub>1</sub>, 0.59 ± 0.67 ng/mL in Q<sub>2</sub>, 1.99 ± 1.65 ng/mL in Q<sub>3</sub>, 4.63 ± 3.57 ng/mL in Q<sub>4</sub> with (p=0.001).</p><p><strong>Conclusions: </strong>This study proved that all three types of combined exercise intensity increased myokine levels, such as irisin and IL-6. However, high-intensity combination exercise provided the most optimal improvement in myokine levels in obese women. Future studies are needed to design long-term exercise programs specifically for obese adolescent women using the findings from this study.</p>","PeriodicalId":15352,"journal":{"name":"Journal of Basic and Clinical Physiology and Pharmacology","volume":" ","pages":"71-78"},"PeriodicalIF":0.0000,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"High-intensity combination exercise has the highest effect on increasing serum irisin and interleukin 6 levels in women with obesity.\",\"authors\":\"Uswatun Hasanah, Purwo Sri Rejeki, Citrawati Dyah Kencono Wungu, Adi Pranoto, Nabilah Izzatunnisa, Ilham Rahmanto, Shariff Halim\",\"doi\":\"10.1515/jbcpp-2023-0150\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objectives: </strong>Lifestyle, overnutrition, socioeconomic status, environmental conditions, and genetics are factors that cause obesity. Lifestyle modification with a nonpharmacological approach based on physical exercise is the starting point in overcoming obesity. However, physical exercise with the appropriate and effective intensity for obese subjects is still debated. Therefore, this study aims to prove the effect of intensity differences with aerobic-resistance combination exercise on increasing irisin and IL-6 levels in obese women.</p><p><strong>Methods: </strong>A total of 32 obese women were selected as subjects and administered the interventions of low-intensity combination exercise (Q<sub>2</sub>), moderate-intensity combination exercise (Q<sub>3</sub>), and high-intensity combination exercise (Q<sub>4</sub>). ELISA was used to measure irisin and IL-6 levels in all samples. Statistical analysis used one-way ANOVA and Turkey's-Honest Significant Difference (HSD) post hoc test.</p><p><strong>Results: </strong>The mean Δ IL-6 levels in the control groups (Q<sub>1</sub>), Q<sub>2</sub>, Q<sub>3</sub>, and Q<sub>4</sub> were 0.27 ± 2.54, 2.07 ± 2.55, 5.99 ± 6.25, and 7.98 ± 2.82 pg/mL with (p=0.015). The mean Δ irisin levels were 0.06 ± 0.81 ng/mL in Q<sub>1</sub>, 0.59 ± 0.67 ng/mL in Q<sub>2</sub>, 1.99 ± 1.65 ng/mL in Q<sub>3</sub>, 4.63 ± 3.57 ng/mL in Q<sub>4</sub> with (p=0.001).</p><p><strong>Conclusions: </strong>This study proved that all three types of combined exercise intensity increased myokine levels, such as irisin and IL-6. However, high-intensity combination exercise provided the most optimal improvement in myokine levels in obese women. Future studies are needed to design long-term exercise programs specifically for obese adolescent women using the findings from this study.</p>\",\"PeriodicalId\":15352,\"journal\":{\"name\":\"Journal of Basic and Clinical Physiology and Pharmacology\",\"volume\":\" \",\"pages\":\"71-78\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-03-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Basic and Clinical Physiology and Pharmacology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1515/jbcpp-2023-0150\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q3\",\"JCRName\":\"Pharmacology, Toxicology and Pharmaceutics\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Basic and Clinical Physiology and Pharmacology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1515/jbcpp-2023-0150","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"Pharmacology, Toxicology and Pharmaceutics","Score":null,"Total":0}
High-intensity combination exercise has the highest effect on increasing serum irisin and interleukin 6 levels in women with obesity.
Objectives: Lifestyle, overnutrition, socioeconomic status, environmental conditions, and genetics are factors that cause obesity. Lifestyle modification with a nonpharmacological approach based on physical exercise is the starting point in overcoming obesity. However, physical exercise with the appropriate and effective intensity for obese subjects is still debated. Therefore, this study aims to prove the effect of intensity differences with aerobic-resistance combination exercise on increasing irisin and IL-6 levels in obese women.
Methods: A total of 32 obese women were selected as subjects and administered the interventions of low-intensity combination exercise (Q2), moderate-intensity combination exercise (Q3), and high-intensity combination exercise (Q4). ELISA was used to measure irisin and IL-6 levels in all samples. Statistical analysis used one-way ANOVA and Turkey's-Honest Significant Difference (HSD) post hoc test.
Results: The mean Δ IL-6 levels in the control groups (Q1), Q2, Q3, and Q4 were 0.27 ± 2.54, 2.07 ± 2.55, 5.99 ± 6.25, and 7.98 ± 2.82 pg/mL with (p=0.015). The mean Δ irisin levels were 0.06 ± 0.81 ng/mL in Q1, 0.59 ± 0.67 ng/mL in Q2, 1.99 ± 1.65 ng/mL in Q3, 4.63 ± 3.57 ng/mL in Q4 with (p=0.001).
Conclusions: This study proved that all three types of combined exercise intensity increased myokine levels, such as irisin and IL-6. However, high-intensity combination exercise provided the most optimal improvement in myokine levels in obese women. Future studies are needed to design long-term exercise programs specifically for obese adolescent women using the findings from this study.
期刊介绍:
The Journal of Basic and Clinical Physiology and Pharmacology (JBCPP) is a peer-reviewed bi-monthly published journal in experimental medicine. JBCPP publishes novel research in the physiological and pharmacological sciences, including brain research; cardiovascular-pulmonary interactions; exercise; thermal control; haematology; immune response; inflammation; metabolism; oxidative stress; and phytotherapy. As the borders between physiology, pharmacology and biochemistry become increasingly blurred, we also welcome papers using cutting-edge techniques in cellular and/or molecular biology to link descriptive or behavioral studies with cellular and molecular mechanisms underlying the integrative processes. Topics: Behavior and Neuroprotection, Reproduction, Genotoxicity and Cytotoxicity, Vascular Conditions, Cardiovascular Function, Cardiovascular-Pulmonary Interactions, Oxidative Stress, Metabolism, Immune Response, Hematological Profile, Inflammation, Infection, Phytotherapy.