职业暴露于金属烟尘 PM2.5 对船厂工人肺功能和生物标志物的影响:一项为期 3 年的前瞻性队列研究。

IF 2.6 3区 医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
Huan Minh Tran, Ching-Huang Lai, Wei-Liang Chen, Chung Ching Wang, Che-Wei Liang, Chi-Yu Chien, Chih-Hong Pan, Kai-Jen Chuang, Hsiao-Chi Chuang
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引用次数: 0

摘要

研究目的本研究调查了α1-抗胰蛋白酶、α-胰蛋白酶间抑制物重链(ITIH4)和8-异前列腺素与暴露于职业性金属烟尘细颗粒物(PM2.5)的船厂工人肺功能的关系:对 180 名船厂工人进行了为期 3 年的跟踪研究,共测量了 262 项数据。收集了一个 8 小时工作日内个人接触焊接烟尘 PM2.5 的情况。使用酶联免疫吸附试验测定了尿液中α1-抗胰蛋白酶、ITIH4和8-异前列腺素的暴露前、暴露后和δ(Δ)水平。暴露后的尿液金属在下一个工作日开始时采样,并通过电感耦合等离子体质谱法进行分析。暴露后的下一个工作日还进行了肺功能测量:结果:PM2.5的IQR增加与FEV1下降2.157%、PEF下降2.806%、FEF25%下降4.328%、FEF50%下降5.047%和FEF75%下降7.205%有关。PM2.5 的 IQR 增加导致 ∆α1- 抗胰蛋白酶增加 42.155 微克/克,∆ITIH4 增加 16.273 微克/克。值得注意的是,各种尿液金属的 IQR 增加与特定生物标志物的增加有关,如尿后 α1-抗胰蛋白酶和 ITIH4。此外,∆ α1-抗胰蛋白酶和∆ITIH4的增加与FEV1/FVC分别下降0.008%和0.020%有关,而∆8-异前列腺素的增加导致FVC下降1.538%:我们的研究表明,尿液中的α1-抗胰蛋白酶和ITIH4可预示暴露于金属烟尘PM2.5的船厂工人肺功能的早期衰退,这强调了加强安全和健康监测以降低呼吸系统风险的必要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Effects of occupational exposure to metal fume PM<sub>2.5</sub> on lung function and biomarkers among shipyard workers: a 3-year prospective cohort study.

Effects of occupational exposure to metal fume PM2.5 on lung function and biomarkers among shipyard workers: a 3-year prospective cohort study.

Objective: This study investigates the associations of α1-antitrypsin, inter-α-trypsin inhibitor heavy chain (ITIH4), and 8-isoprostane with lung function in shipyard workers exposed to occupational metal fume fine particulate matter (PM2.5), which is known to be associated with adverse respiratory outcomes.

Methods: A 3-year follow-up study was conducted on 180 shipyard workers with 262 measurements. Personal exposure to welding fume PM2.5 was collected for an 8-h working day. Pre-exposure, post-exposure, and delta (∆) levels of α1-antitrypsin, ITIH4, and 8-isoprostane were determined in urine using enzyme-linked immunosorbent assays. Post-exposure urinary metals were sampled at the beginning of the next working day and analyzed by inductively coupled plasma-mass spectrometry. Lung function measurements were also conducted the next working day for post-exposure.

Results: An IQR increase in PM2.5 was associated with decreases of 2.157% in FEV1, 2.806% in PEF, 4.328% in FEF25%, 5.047% in FEF50%, and 7.205% in FEF75%. An IQR increase in PM2.5 led to increases of 42.155 µg/g in ∆α1-antitrypsin and 16.273 µg/g in ∆ITIH4. Notably, IQR increases in various urinary metals were associated with increases in specific biomarkers, such as post-urinary α1-antitrypsin and ITIH4. Moreover, increases in ∆ α1-antitrypsin and ∆ITIH4 were associated with decreases in FEV1/FVC by 0.008% and 0.020%, respectively, and an increase in ∆8-isoprostane resulted in a 1.538% decline in FVC.

Conclusion: Our study suggests that urinary α1-antitrypsin and ITIH4 could indicate early lung function decline in shipyard workers exposed to metal fume PM2.5, underscoring the need for better safety and health monitoring to reduce respiratory risks.

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来源期刊
International Archives of Occupational and Environmental Health
International Archives of Occupational and Environmental Health 医学-公共卫生、环境卫生与职业卫生
CiteScore
5.60
自引率
6.70%
发文量
127
审稿时长
3 months
期刊介绍: International Archives of Occupational and Environmental Health publishes Editorials, Review Articles, Original Articles, and Letters to the Editor. It welcomes any manuscripts dealing with occupational or ambient environmental problems, with a special interest in research at the interface of occupational health and clinical medicine. The scope ranges from Biological Monitoring to Dermatology, from Fibers and Dust to Human Toxicology, from Nanomaterials and Ultra-fine Dust to Night- and Shift Work, from Psycho-mental Distress and Burnout to Vibrations. A complete list of topics can be found on the right-hand side under For authors and editors. In addition, all papers should be based on present-day standards and relate to: -Clinical and epidemiological studies on morbidity and mortality -Clinical epidemiological studies on the parameters relevant to the estimation of health risks -Human experimental studies on environmental health effects. Animal experiments are only acceptable if relevant to pathogenic aspects. -Methods for studying the topics mentioned above.
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